Results 41 to 50 of about 5,594 (243)

Glycobiology of the olfactory system [PDF]

, 1998
The olfactory system is a highly plastic region of the nervous system. Continuous remodeling of neuronal circuits in the olfactory bulb takes place throughout life as a result of constant turnover of primary sensory olfactory neurons in the periphery ...
Plendl, J., Sinowatz, Fred
core   +1 more source

Desialylation of Atg5 by sialidase (Neu2) enhances autophagosome formation to induce anchorage-dependent cell death in ovarian cancer cells

Cell Death Discovery, 2021
Increased sialylation is one of the hallmarks of ovarian cancer (OC) but its relation with programmed cell death is not known. Here we explored the molecular interplay between autophagy, apoptosis/anoikis, and aberrant-expression of the PI3K-Akt/mTOR ...
Eswara Murali Satyavarapu, Shalini Nath, Chitra Mandal   +2 more
doaj   +1 more source

Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells. [PDF]

, 1990
We studied the cell-surface delivery pathways of newly synthesized membrane glycoproteins in MDCK cells and for this purpose we characterized an endogenous apical integral membrane glycoprotein.
Le Bivic, A, Mostov, K, Rodriguez-Boulan, E, Sambuy, Y   +3 more
core  

Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies [PDF]

, 2013
Clostridium perfringens epsilon toxin (Etx) is a pore-forming toxin responsible for a severe and rapidly fatal enterotoxemia of ruminants. The toxin is classified as a category B bioterrorism agent by the U.S.
Abe, Abrami, Bhown, Bokori-Brown, Chassin, Cole, Davis, De Colibus, Diep, Dorca-Arevalo, Emsley, Finnie, Ivie, Ivie, Jin, Knight, Lavinder, Lonchamp, McClain, McCoy, McDonel, Minami, Miyamoto, Miyamoto, Miyata, Murshudov, Nagahama, Nagahama, Nagahama, Oyston, Parker, Payne, Pelish, Petit, Pflugrath, Popoff, Popoff, Recommendations of the CDC Strategic Planning Workgroup, Songer, Uzal, Winn   +40 more
core   +1 more source

Antitumor Activities by a Humanized Cancer‐Specific Anti‐Podoplanin Monoclonal Antibody humPMab‐117 Against Human Tumors

Cancer Science, EarlyView.
A humanized cancer‐specific anti‐podoplanin monoclonal antibody humPMab‐117 exerts antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against human tumor cells. In the xenograft tumor models, humPMab‐117 demonstrated strong antitumor efficacy.
Tomohiro Tanaka, Hiroyuki Suzuki, Tomokazu Ohishi, Manabu Kawada, Mika K. Kaneko, Yukinari Kato   +5 more
wiley   +1 more source

E‐selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor‐prognosis signature in colorectal cancer

Molecular Oncology, Volume 19, Issue 3, Page 635-658, March 2025.
Screening colorectal tumors for glycoproteins linked to disease progression has revealed several potential therapeutic targets. The secretin receptor (SCTR), identified as a marker of poor prognosis and metastasis in colorectal cancer, has been shown to be a key carrier of N‐glycans with sialylated Lewis antigens. These cancer‐specific glycoproteoforms
Sofia Cotton, Dylan Ferreira, Marta Relvas‐Santos, Andreia Brandão, Luís Pedro Afonso, Andreia Miranda, Eduardo Ferreira, Beatriz Santos, Martina Gonçalves, Paula Lopes, Lúcio Lara Santos, André M. N. Silva, José Alexandre Ferreira   +12 more
wiley   +1 more source

The Binding Affinity and Molecular Basis of the Structure-Binding Relationship between Urinary Tamm-Horsfall Glycoprotein and Tumor Necrosis Factor-α

Molecules, 2012
In a previous study we noted significant THP binding to TNF-α, but did not explore the molecular basis of the structure-binding relationship. In this study, we used lectin-binding ELISA to assess the carbohydrate compositions of THP, BSA, IgG, TNF-α, and
Chia-Li Yu, Chang-Youh Tsai, Tsai-Hung Wu, Sue-Cien Siao, Yu-Hsuan Chen, Ko-Jen Li, Cheng-Han Wu   +6 more
doaj   +1 more source

Value of immunohistochemical expression of podocalyxin in active lupus nephritis

Nefrología, 2018
Podocalyxin is an electronegative sialoglycoprotein that prevents the podocyte foot process from collapsing. The aim of this study was to detect an association between the glomerular immunohistochemical (IHC) expression of podocalyxin and the degree of ...
Maha Abdelmoneim Behairy, Marwa Mosaad Shakweer, Tamer Wahid El Said, Nermin Hassan ElGharbawy   +3 more
doaj   +3 more sources

Know Your ABCs: Discovery, Differentiation, and Targeting of T‐Bet+ B Cells

Immunological Reviews, Volume 330, Issue 1, March 2025.
ABSTRACT Since their first description in 2008, T‐bet+ B cells have emerged as a clinically important B cell subset. Now commonly known as ABCs (Age‐associated B Cells), they are uniquely characterized by their expression of the transcription factor T‐bet. Indeed, this singular factor defines this B cell subset.
Gary M. Winslow, Russell Levack
wiley   +1 more source

Issue Information

, 2023
Journal of Cosmetic Dermatology, Volume 22, Issue 12, Page 3195-3196, December 2023.
wiley   +1 more source