Results 131 to 140 of about 4,367 (168)

Increased expression of sialyl Lewis A and sialyl Lewis X in liver metastases of human colorectal carcinoma.

Invasion & metastasis, 1996
Sialyl Lewis A (SLA) and sialyl Lewis X (SLX) have been shown to be specific ligands for endothelial leukocyte adhesion molecule-1 (ELAM-1), and may be involved in the process of adhesion between cancer cells and endothelium. We used immunohistochemical methods to study the expression of SLA, SLX and CEA in both primary tumors and matched metastatic ...
N, Yamada, Y S, Chung, K, Maeda, T, Sawada, T, Ikehara, H, Nishino, M, Okuno, M, Sowa   +7 more
openaire   +1 more source

Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression—The Warburg effect revisited

Glycoconjugate Journal, 2003
Cell adhesion mediated by selectins and their carbohydrate ligands, sialyl Lewis X and sialyl Lewis A, figures heavily in cancer metastasis. Expression of these carbohydrate determinants is markedly enhanced in cancer cells, but the molecular mechanism that leads to cancer-associated expression of sialyl Lewis X/A has not been well understood.
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Transiently binding antibody fragments against Lewis x and sialyl-Lewis x

Journal of Immunological Methods, 2006
Biomolecular recognition is often characterised by low affinity where many weak interactions work either alone or in concert, resulting in an inherent dynamic situation. For example the well-studied weak binding of cell-cell interactions is predominantly based on a range of carbohydrates that interact with numerous (protein) ligands.
Reine, Johansson, Mats, Ohlin, Bo, Jansson, Sten, Ohlson   +3 more
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Expression of sialyl Lewis(x) in hepatocellular carcinoma.

Hepato-gastroenterology, 1996
Expression of the sialyl Lewis(x) antigen, a cell adhesion molecule, was studied immunohistochemically in patients with hepatocellular carcinomas.Fifty-six patients who underwent curative hepatic resections from July 1984 to October 1990 were studied.Hepatocellular staining patterns of the sialyl Lewis(x) in cancerous or noncancerous regions were ...
A, Tori, A, Harada, A, Nakao, T, Nonami, M, Ito, H, Takagi   +5 more
openaire   +1 more source

Synthesis of novel mimetics of the sialyl Lewis X determinant

Tetrahedron Letters, 1995
Abstract Mimctics of the sialyl Lewis-X determinant in which at least one sugar domain is simulated by a di-, tri- or tetraalcohol unit have been synthesized. The inhibitory potency of these compounds for E- and P-selectin mediated cell adhesion has been evaluated in cell culture assays. The receptor binding affinity of the best of these mimetics was
Alexander Toepfer, Gerhard Kretzschmar, Eckart Bartnik   +2 more
openaire   +1 more source

A convenient and efficient synthesis of sialyl Lewis X.

Bioscience, biotechnology, and biochemistry, 1998
A convenient synthesis of the sialyl Lewis X (sLe(x)) tetrasaccharide, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc (8), as a carbohydrate ligand for selectins is described. The key step is the reaction between NeuAc alpha 2-3GalSMe (5) as a glycosyl donor and the suitably protected Fuc alpha 1-3GlcNAc derivative (4) as the glycosyl acceptor by ...
K, Baba, N, Iwata, H, Hamajima, T, Ikami, H, Ishida, A, Hasegawa, M, Kiso   +6 more
openaire   +1 more source

Expression of the carbohydrate antigens Sialyl Lewis a, Sialyl Lewis x and Lewis x in the placentae of patients with miscarriages

Geburtshilfe und Frauenheilkunde, 2020
Z Ma, L Peng, H Yang, C Kuhn, S Mahner, U Jeschke, V von Schönfeldt   +6 more
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Total synthesis of sialyl Lewis X

Carbohydrate Research, 1991
A, Kameyama, H, Ishida, M, Kiso, A, Hasegawa   +3 more
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Novel mimics of sialyl Lewis X

Bioorganic & Medicinal Chemistry, 2001
Anne Marinier, Alain Martel, Carol Bachand, Serge Plamondon, Brigitte Turmel, Jean-Paul Daris, Jacques Banville, Philippe Lapointe, Carl Ouellet, Pierre Dextraze, Marcel Menard, John J.K Wright, Julie Alford, Debbie Lee, Paul Stanley, Xina Nair, Gordon Todderud, Kenneth M Tramposch   +17 more
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Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium.

Cancer research, 1993
The carbohydrate antigen, sialyl Lex, is known to be a ligand for the cell adhesion molecule called ELAM-1 (E-selectin, endothelial cell leukocyte adhesion molecule-1), which is present on cytokine-activated human endothelial cells. Recently, we reported that another carbohydrate antigen, sialyl Lea, can also serve as a ligand for ELAM-1 (A. Takada, K.
A, Takada, K, Ohmori, T, Yoneda, K, Tsuyuoka, A, Hasegawa, M, Kiso, R, Kannagi   +6 more
openaire   +1 more source