Results 121 to 130 of about 4,367 (168)

A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis

Nature, 1993
To identify cell adhesion molecules required for angiogenesis, we used an in vitro model in which bovine capillary endothelial cells can be induced to form capillary-like tubes. Monoclonal antibodies directed against the carbohydrate epitopes sialyl Lewis-X and sialyl Lewis-A inhibited capillary formation.
M, Nguyen, N A, Strubel, J, Bischoff
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A novel mimic of the sialyl Lewis x determinant

Tetrahedron Letters, 1993
Abstract The syntheses of two novel disaccharides are described which block the interaction of the lectin domain of E-selectin with its glycosylated ligands on neutrophils.
Nigel M. Allanson, Alan H. Davidson, Fionna M. Martin   +2 more
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Synthesis of a novel analogue of sialyl Lewis X

Tetrahedron Letters, 1995
Abstract Two different strategies have been developed in order to synthesise an analogue and potential mimic of sialyl Lewis X that incorporates a carboxymethyl group and a C 2 -symmetric 2,3-butanediol unit as replacements for the sialic acid and the N-acetylglucosamine residues respectively.
Jeremy C. Prodger, Mark J. Bamford, Paul M. Gore, Duncan S. Holmes, Victoria Saez, Peter Ward   +5 more
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Synthesis and Molecular Tumbling Properties of Sialyl Lewis X and Derived Neoglycolipids

Chemistry - A European Journal, 2002
The sialyl Lewis X (sLeX) epitope has become a prominent target for biological studies because of its role in inflammation through binding to selectins. This epitope is located at the terminal end in glycosphingolipids and a lactose unit serves as spacer to the ceramide moiety.
Christian Gege, Armin Geyer, Richard R Schmidt   +2 more
exaly   +3 more sources

Sialyl Lewis^x: A “Pre‐Organized Water Oligomer”?

Angewandte Chemie International Edition, 2012
Organized and released: Sialyl Lewis(x) (sLe(x)) represents a "pre-organized water oligomer", that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLe(x) binding to E-selectin is shown to be the high degree of pre-organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of ...
Binder, Florian P. C., Lemme, Katrin, Preston, Roland C., Ernst, Beat   +3 more
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Sialyl Lewis X-polysaccharide conjugates: Targeting inflammatory lesions

Bioorganic & Medicinal Chemistry Letters, 1998
A novel system for active targeting of inflammatory lesions has been established. A SLeX-CMPul conjugate (2) showed accumulation that was 2.5-fold higher in inflammatory lesions in vivo than a SLN-CMPul conjugate (4) and 300-fold higher than monovalent SLeX (6).
M, Sakagami, K, Horie, K, Nakamoto, T, Kawaguchi, H, Hamana   +4 more
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[Clinical value of carbohydrate antigens, sialyl Lewis-x and sialyl Lewis-a in gastrointestinal cancer].

Nihon Geka Gakkai zasshi, 1996
To evaluate clinical importance of the expression of sialyl Lewis-X (sLe(x)) and sialyl Lewis-a antigen (sLe(a)) in gastrointestinal cancers, we examined immunohistochemically expression of the two antigens in esophageal, gastric, colorectal, and pancreatic cancer.
S, Nakamori, I, Arai, S, Okamura, S, Imaoka, H, Furukawa, T, Kabuto, O, Ishikawa, Y, Sasaki, M, Kameyama, T, Iwanaga   +9 more
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In vitro experimental studies of sialyl Lewis x and sialyl Lewis a on endothelial and carcinoma cells: crucial glycans on selectin ligands

Glycoconjugate Journal, 1997
Extravasation from the blood of malignant tumour cells that form metastasis and leukocytes that go into tissues require contact between selectins and their sialyl Lewis x and sialyl Lewis a (sLe(x) and sLe(a) respectively) decorated ligands. Endothelial cells have been shown to express sLe(x) epitopes in lymph nodes and at sites of inflammation, and ...
R, Renkonen, P, Mattila, M L, Majuri, J, Räbinä, S, Toppila, J, Renkonen, L, Hirvas, J, Niittymäki, J P, Turunen, O, Renkonen, T, Paavonen   +10 more
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Synthesis of a Sialyl Lewis x Mimic with Fixed Carboxylic Acid Group:  Chemical Approach toward the Elucidation of the Bioactive Conformation of Sialyl Lewis x

The Journal of Organic Chemistry, 1996
The relation of the solution and bioactive conformation of sialyl Lewis x (sLe(x)) has been addressed by chemical means. To mimic the preferred solution conformation of sLe(x) 1, the more rigid analog 2 has been designed and synthesized. The sialic acid residue of 1 was replaced by a carboxylic acid function which is fixed in the equatorial position of
Gebhard, Thoma, Franz, Schwarzenbach, Rudolf O., Duthaler   +2 more
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An Economical Synthesis of Lewis X, Sialyl Lewis X and Their α-Galactosyl Analogues

Journal of Carbohydrate Chemistry, 1997
Economical syntheses of the Lewis X trisaccharide 8 and sialyl Lewis X tetrasaccharide 18 epitopes and the syntheses of the α-galactosyl epimers 9 and 20 of these structures are described. Thioglycosides 2, 5, 11 and 15 were used as glycosyl donors to construct the desired compounds in a stepwise manner in dimethyl(methylthio)sulphonium triflate ...
Dekany, Gyula, Wright, Karen, Toth, Istvan   +2 more
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