Results 1 to 10 of about 1,731,278 (307)

Glycan Stability and Flexibility: Thermodynamic and Kinetic Characterization of Nonconventional Hydrogen Bonding in Lewis Antigens. [PDF]

J Am Chem Soc, 2023
We provide evidence for CH-based nonconventional hydrogen bonds (H-bonds) for 10 Lewis antigens and two of their rhamnose analogues. We also characterize the thermodynamics and kinetics of the H-bonds in these molecules and present a plausible ...
Kwon J, Ruda A, Azurmendi HF, Zarb J, Battistel MD, Liao L, Asnani A, Auzanneau FI, Widmalm G, Freedberg DI.   +9 more
europepmc   +4 more sources

H. pylori α1-3/4-fucosyltransferase (Hp3/4FT)-catalyzed one-pot multienzyme (OPME) synthesis of Lewis antigens and human milk fucosides. [PDF]

Chem Commun (Camb), 2017
Helicobacter pylori α1–3/4-fucosyltransferase (Hp3/4FT) was expressed in Escherichia coli at a level of 30 mg/L culture and used as a diverse catalyst in a one-pot multienzyme (OPME) system for high-yield production of L-fucose-containing carbohydrates ...
Yu H, Li Y, Wu Z, Li L, Zeng J, Zhao C, Wu Y, Tasnima N, Wang J, Liu H, Gadi MR, Guan W, Wang PG, Chen X.   +13 more
europepmc   +4 more sources

Antibodies against Lewis antigens inhibit the binding of human norovirus GII.4 virus-like particles to saliva but not to intestinal Caco-2 cells. [PDF]

Virol J, 2016
Human noroviruses (NoVs) are the main cause of gastroenteritis worldwide. The most commonly detected NoV strains belong to the genetically diverse GII.4 genotype, with new pandemic variants emerging periodically.
Carmona-Vicente N, Allen DJ, Rodríguez-Díaz J, Iturriza-Gómara M, Buesa J.   +4 more
europepmc   +5 more sources

Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages [PDF]

Frontiers in Immunology, 2021
BackgroundLewis antigens such as Sialyl Lewis A (sLeA), Sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are a class of carbohydrate molecules that are known to mediate adhesion between tumor cells and endothelium by interacting with its selectin ...
Zhi Ma, Huixia Yang, Lin Peng, Christina Kuhn, Anca Chelariu-Raicu, Sven Mahner, Udo Jeschke, Udo Jeschke, Viktoria von Schönfeldt   +8 more
doaj   +7 more sources

Lewis fucose is a key moiety for the recognition of histo‐blood group antigens by GI.9 norovirus, as revealed by structural analysis

FEBS Open Bio, 2022
Noroviruses have been identified as major causative agents of acute nonbacterial gastroenteritis in humans. Histo‐blood group antigens (HBGAs) are thought to play a major role among the host cellular factors influencing norovirus infection.
Tomomi Kimura-Someya, Miyuki Kato-Murayama, Kazushige Katsura   +2 more
exaly   +2 more sources

H pylori and Lewis antigens [PDF]

Gut, 2000
See article on page 18 Lipopolysaccharide (LPS) of many Helicobacter pylori strains expresses Lewis antigens (Lex, Ley, Lea, Leb) which are similar to those expressed by gastric epithelial cells (“molecular mimicry”).1 In addition, H pylori LPS displays phase variation in these antigens—that is, the high frequency, reversible switching of phenotype2;
B J, Appelmelk, C M, Vandenbroucke-Grauls   +1 more
openaire   +3 more sources

Infant Botulism and Carbohydrate Blood Group Antigens: Preliminary Results from a Discordant Twin Study [PDF]

Journal of Pediatrics: Clinical Practice
Objective: We investigated if specific carbohydrate blood group antigens were associated with infant botulism (IB) among discordant twins and triplets.
Haydee A. Dabritz, PhD, Mayuri V. Panditrao, PhD, MPH, Suchitra Pandey, MD, Nir Dover, PhD, Jason R. Barash, CLS, MT(ASCP), Jessica M. Khouri, MD, Jennifer S. Read, MD, MS, MPH   +6 more
doaj   +2 more sources

Structural basis for the recognition of Lewis antigens by genogroup I norovirus. [PDF]

J Virol, 2012
Kubota T, Kumagai A, Ito H, Furukawa S, Someya Y, Takeda N, Ishii K, Wakita T, Narimatsu H, Shirato H.   +9 more
europepmc   +2 more sources

Molecular mechanisms of expression of Lewis b antigen and other Type I Lewis antigens in human colorectal cancer

Glycobiology, 1999
Lewis b (Leb) antigens are gradiently expressed from the proximal to the distal colon, i.e., they are abundantly expressed in the proximal colon, but only faintly in the distal colon. In the distal colon, they begin to increase at the adenoma stage of cancer development and then increase with cancer progression.
S, Nishihara, T, Hiraga, Y, Ikehara, T, Kudo, H, Iwasaki, K, Morozumi, S, Akamatsu, T, Tachikawa, H, Narimatsu   +8 more
openaire   +3 more sources

The expression of ABH and Lewis antigens in Brazilian semi-isolated Black communities

Genetics and Molecular Biology, 2002
The expression of the ABH and Lewis blood groups was determined in blood and saliva samples from two semi-isolated Black communities of Northern Brazil: Cametá and Alcântara.
Tereza Cristina OLiveira Corvelo, D.C.F. Aguiar, F.E.S. Sagica   +2 more
doaj   +2 more sources