Results 1 to 10 of about 845,922 (255)

Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages [PDF]

Frontiers in Immunology, 2021
BackgroundLewis antigens such as Sialyl Lewis A (sLeA), Sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are a class of carbohydrate molecules that are known to mediate adhesion between tumor cells and endothelium by interacting with its selectin ...
Zhi Ma, Huixia Yang, Lin Peng, Christina Kuhn, Anca Chelariu-Raicu, Sven Mahner, Udo Jeschke, Udo Jeschke, Viktoria von Schönfeldt   +8 more
doaj   +5 more sources

Targeting Aberrantly Elevated Sialyl Lewis A as a Potential Therapy for Impaired Endometrial Selection Ability in Unexplained Recurrent Miscarriage

Frontiers in Immunology, 2022
BackgroundCarbohydrate Lewis antigens including sialyl Lewis A (sLeA), sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are the commonest cell surface glycoconjugates that play pivotal roles in multiple biological processes, including cell ...
Zhi Ma, Huixia Yang, Mirjana Kessler, Markus Sperandio, Sven Mahner, Udo Jeschke, Udo Jeschke, Viktoria von Schönfeldt   +7 more
doaj   +1 more source

Differential H. pylori-Induced MAPK Responses Regulate Lewis Antigen Expression and Colonization Density on Gastric Epithelial Cells Between Children and Adults

Frontiers in Immunology, 2022
Helicobacter pylori causes gastrointestinal diseases, the manifestations of diseases are more serious in adults than in children. Lewis antigen expressions on the gastric epithelium serves as receptors targeted by H. pylori.
Yao-Jong Yang, Yao-Jong Yang, Chia-Ling Lu, Bor-Shyang Sheu, Bor-Shyang Sheu   +4 more
doaj   +1 more source

Lewis fucose is a key moiety for the recognition of histo‐blood group antigens by GI.9 norovirus, as revealed by structural analysis

FEBS Open Bio, 2022
Noroviruses have been identified as major causative agents of acute nonbacterial gastroenteritis in humans. Histo‐blood group antigens (HBGAs) are thought to play a major role among the host cellular factors influencing norovirus infection.
Tomomi Kimura‐Someya, Miyuki Kato‐Murayama, Kazushige Katsura, Naoki Sakai, Kazutaka Murayama, Kazuharu Hanada, Mikako Shirouzu, Yuichi Someya   +7 more
doaj   +1 more source

The Lewis histo-blood group system: molecular analysis of the 59T>G, 508G>A, and 1067T>A polymorphisms in an Amazonian population. [PDF]

PLoS ONE, 2013
BACKGROUND: The Lewis (FUT3) gene is responsible for the expression of the Le(a) and Le(b) blood group antigens. The individuals, who not synthesize these antigens have the phenotype Lewis negative, due to the presence of some single nucleotide ...
Tereza Cristina de Oliveira Corvelo, Rosane do Socorro Pompeu de Loiola, Délia Cristina Figueira Aguiar, Gyselly de Cássia Bastos de Matos, Danielle Calado de Brito   +4 more
doaj   +1 more source

Individuals with Le(a+b-) blood group have increased susceptibility to symptomatic vibrio cholerae O1 infection. [PDF]

PLoS Neglected Tropical Diseases, 2011
Human genetic factors such as blood group antigens may affect the severity of infectious diseases. Presence of specific ABO and Lewis blood group antigens has been shown previously to be associated with the risk of different enteric infections.
Mohammad Arifuzzaman, Tanvir Ahmed, Mohammad Arif Rahman, Fahima Chowdhury, Rasheduzzaman Rashu, Ashraful I Khan, Regina C LaRocque, Jason B Harris, Taufiqur Rahman Bhuiyan, Edward T Ryan, Stephen B Calderwood, Firdausi Qadri   +11 more
doaj   +1 more source

Importance of Phenotyping Minor Blood Group Antigen in Renal Transplant Donors: A Retrospective Cohort Study [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Various studies have implicated minor antigens with increased graft rejection in the long term, especially in alloimmunised patients. Recipient’s antibody testing is done exhaustively during each case of rejection. However, without data
Sujata Mallick, Mahasweta Mallik, Puskar Shyam Chowdhury   +2 more
doaj   +1 more source

The Association between Symptomatic Rotavirus Infection and Histo-Blood Group Antigens in Young Children with Diarrhea in Pretoria, South Africa

Viruses, 2022
Objectives: Recently, histo-blood group antigens (HBGAs) have been identified as receptors or attachment factors of several viral pathogens. Among rotaviruses, HBGAs interact with the outer viral protein, VP4, which has been identified as a potential ...
Kebareng Rakau, Maemu Gededzha, Ina Peenze, Pengwei Huang, Ming Tan, Andrew Duncan Steele, Luyanda Mapaseka Seheri   +6 more
doaj   +1 more source

High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers. [PDF]

PLoS ONE, 2013
OBJECTIVES:To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.
Zhenhua Hu, Jian Gao, Danye Zhang, Qing Liu, Limei Yan, Lili Gao, Juanjuan Liu, Dawo Liu, Shulan Zhang, Bei Lin   +9 more
doaj   +1 more source

Helicobacter pylori BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development

Toxins, 2021
Helicobacter pylori is a pathogenic microorganism that successfully inhabits the human stomach, colonizing it by producing several virulence factors responsible for preventing host self-defense mechanisms.
Dalla Doohan, Yudith Annisa Ayu Rezkitha, Langgeng Agung Waskito, Yoshio Yamaoka, Muhammad Miftahussurur   +4 more
doaj   +1 more source