Complementary Use of Carbohydrate Antigens Lewis a, Lewis b, and Sialyl-Lewis a (CA19.9 Epitope) in Gastrointestinal Cancers: Biological Rationale towards a Personalized Clinical Application [PDF]
Cancers, 2020 Carbohydrate antigen 19.9 (CA19.9) is used as a tumor marker for clinical and research purposes assuming that it is abundantly produced by gastrointestinal cancer cells due to a cancer-associated aberrant glycosylation favoring its synthesis. Recent data
Rossella Indellicato +3 more
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Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens. [PDF]
PLoS Pathogens, 2011 Noroviruses, an important cause of acute gastroenteritis in humans, recognize the histo-blood group antigens (HBGAs) as host susceptible factors in a strain-specific manner.
Yutao Chen +8 more
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Frontiers in Immunology, 2022 BackgroundCarbohydrate Lewis antigens including sialyl Lewis A (sLeA), sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are the commonest cell surface glycoconjugates that play pivotal roles in multiple biological processes, including cell ...
Zhi Ma +7 more
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Frontiers in Immunology, 2022 Helicobacter pylori causes gastrointestinal diseases, the manifestations of diseases are more serious in adults than in children. Lewis antigen expressions on the gastric epithelium serves as receptors targeted by H. pylori.
Yao-Jong Yang +4 more
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The Lewis histo-blood group system: molecular analysis of the 59T>G, 508G>A, and 1067T>A polymorphisms in an Amazonian population. [PDF]
PLoS ONE, 2013 BACKGROUND: The Lewis (FUT3) gene is responsible for the expression of the Le(a) and Le(b) blood group antigens. The individuals, who not synthesize these antigens have the phenotype Lewis negative, due to the presence of some single nucleotide ...
Tereza Cristina de Oliveira Corvelo +4 more
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Individuals with Le(a+b-) blood group have increased susceptibility to symptomatic vibrio cholerae O1 infection. [PDF]
PLoS Neglected Tropical Diseases, 2011 Human genetic factors such as blood group antigens may affect the severity of infectious diseases. Presence of specific ABO and Lewis blood group antigens has been shown previously to be associated with the risk of different enteric infections.
Mohammad Arifuzzaman +11 more
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Importance of Phenotyping Minor Blood Group Antigen in Renal Transplant Donors: A Retrospective Cohort Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Various studies have implicated minor antigens with increased graft rejection in the long term, especially in alloimmunised patients. Recipient’s antibody testing is done exhaustively during each case of rejection. However, without data
Sujata Mallick +2 more
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Toxins, 2021 Helicobacter pylori is a pathogenic microorganism that successfully inhabits the human stomach, colonizing it by producing several virulence factors responsible for preventing host self-defense mechanisms.
Dalla Doohan +4 more
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High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers. [PDF]
PLoS ONE, 2013 OBJECTIVES:To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy.
Zhenhua Hu +9 more
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Viruses, 2022 Objectives: Recently, histo-blood group antigens (HBGAs) have been identified as receptors or attachment factors of several viral pathogens. Among rotaviruses, HBGAs interact with the outer viral protein, VP4, which has been identified as a potential ...
Kebareng Rakau +6 more
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