Results 21 to 30 of about 4,367 (168)
Human noroviruses recognize sialyl Lewis x neoglycoprotein [PDF]
Glycobiology, 2008 The carbohydrate binding characteristics of a norovirus GII.3 (Chron1) and a GII.4 (Dijon) strain were investigated using virus-like particles (VLPs) and saliva samples from 81 individuals genotyped for FUT2 (secretor) and FUT3 (Lewis) and phenotyped for ABO and Lewis blood groups. The two VLPs showed a typical secretor-gene-dependent binding and bound
Rydell, G.E. +6 more
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Molecules, 2022 Sialyl 6-sulfo Lewis X (6-sulfo sLeX) and its derivative sialyl 6-sulfo N-acetyllactosamine (LacNAc) are sialylated and sulfated glycans of sialomucins found in the high endothelial venules (HEVs) of secondary lymphoid organs. A component of 6-sulfo sLeX
Yoshiko Takeda-Uchimura +7 more
doaj +1 more source
PLoS ONE, 2009 BackgroundThe process of metastasis involves a series of steps and interactions between the tumor embolus and the microenvironment. Key alterations in adhesion molecules are known to dictate progression from the invasive to malignant phenotype followed ...
Salomé S Pinho +3 more
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Synthesis of Sialyl Lewis X-Polysaccharide Conjugates.
Chemical and Pharmaceutical Bulletin, 2000 Sialyl Lewis X (SLeX) is well known as a ligand of the cell adhesion molecule E-selectin which is specifically expressed at inflammatory lesion sites. We have synthesized several SLeX-polysaccharide conjugates and examined their potential for drug delivery to inflammatory lesions.
SAKAGAMI, Masahiro +4 more
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Structural and Molecular Insights into AipA and OmpA: Key Drivers of Anaplasma phagocytophilum Host Cell Invasion [PDF]
Modern MedicineBackground: This analysis investigates invasion tactics of Anaplasma phagocytophilum which constitutes a gram-negative bacterial species that causes the tick-borne pathogen known as human granulocytic anaplasmosis (HGA).
Ali Adel DAWOOD +2 more
doaj +1 more source
Lewis X and Sialyl Lewis X Glycosphingolipids.
Trends in Glycoscience and Glycotechnology, 1997 ルイスX (Lex) とシアリルルイスX (sLex) は、細胞接着に重要な血液型糖鎖抗原である。細胞膜において、LexとsLexは糖タンパク質やスフィンゴ糖脂質 (GSLs) 上に発現されていると思われる。糖脂質は、オリゴ糖鎖分子がセラミドという脂質の末端に共有結合で結ばれた複雑な高分子である。糖脂質に発現されたLexとsLex糖鎖は、糖タンパク質と同様に、単純なもの、高度にフコシル化されたもの、複合型のもの、分枝したもの、あるいは長鎖のものが存在する。LexとsLexの発現の発生段階における変化は、胎児の発達や器官形成に重要であると考えられる。好中球や血小板上のsLex抗原を持つスフィンゴ糖脂質は、血小板や好中球のローリングを制御していると思われる活性化された血管の内皮細胞に発現されるE ...
Cooling, Laura L. W. +2 more
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Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface
Journal of Nanobiotechnology, 2021 Background Sialyl-Lewis X/L-selectin high affinity binding interactions between transmembrane O-glycosylated mucins proteins and the embryo have been implicated in implantation processes within the human reproductive system.
Lewis W. Francis +13 more
doaj +1 more source
Canadian Journal of Gastroenterology, 2000 BACKGROUND: Altered expression of blood group-related carbohydrate antigens such as sialyl Lewis (Le)x antigen in tumours is associated with tumour progression behaviour and subsequent prognosis.
Tohru Nakagoe +11 more
doaj +1 more source
Diagnostic Pathology, 2011 Background To elucidate relations of invasion of ulcerative colitis (UC)-associated carcinoma with its prognosis, the characteristics of invasive fronts were analyzed in comparison with sporadic colonic carcinomas.
Araki Kayo +6 more
doaj +1 more source
A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts. [PDF]
PLoS Computational Biology, 2016 O-linked glycosylation is an important post-translational modification of mucin-type protein, changes to which are important biomarkers of cancer. For this study of the enzymes of O-glycosylation, we developed a shorthand notation for representing GalNAc-
Andrew G McDonald +2 more
doaj +1 more source