Results 111 to 120 of about 105,245 (307)
British Journal of Haematology, EarlyView.Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê +3 more
wiley +1 more source
BMC Public HealthBackground Sickle cell disease (SCD) is a debilitating hereditary medical condition associated with pain, stigma, morbidity, and early death. To reduce the prevalence and improve the quality of life of persons with SCD, improved knowledge, practices and ...
Peninah Agaba +4 more
doaj +1 more source
Mission: To improve quality of life, life expectancy, and health among people living with sickle cell disease (SCD)
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Steps to Better Kidney Health for People with Sickle Cell Disease [PDF]
People with sickle cell disease (SCD) are at greater risk than the general population for kidney complications. Share your medical history with your healthcare team so it can properly identify and treat any complications of SCD you currently have or may ...
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British Journal of Haematology, EarlyView.Summary Haemoglobin SC (HbSC) disease is the second most prevalent form of sickle cell disease, but evidence for hydroxyurea (hydroxycarbamide; HU) to prevent pain episodes was limited until the prospective identification of variables as outcomes for treatment (PIVOT) trial.
Alice Girard +10 more
wiley +1 more source
Mission: To improve quality of life, life expectancy, and health among people living with sickle cell disease (SCD)
core
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Sickle Cell and Altitude [PDF]
BMJ, 1972 R L, Green, R G, Huntsman, G R, Serjeant
openaire +2 more sources
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
Asthma and Multimorbidity Amongst Ethnic Minority Groups in High Income Countries
Clinical &Experimental Allergy, EarlyView.There is a tight intersection between asthma, deprivation, ethnicity, multimorbidity and poor clinical outcomes. An integrated, holistic and culturally tailored approach is needed to improve clinical outcomes amongst ethnic minority groups with asthma and multimorbidity. ABSTRACT Asthma is one of the commonest noncommunicable diseases worldwide.
Mamidipudi Thirumala Krishna +6 more
wiley +1 more source