Results 61 to 70 of about 105,245 (307)
British Journal of Clinical Pharmacology, EarlyView.Aim A prior non‐randomized study suggests that potassium supplementation may improve survival among furosemide initiators, and a randomized trial suggests that salt substitutes containing potassium might lower stroke risk. We conducted a retrospective cohort study using health‐care data to confirm or refute these associations among new users of ...
Thanh Phuong Pham Nguyen +8 more
wiley +1 more source
Advanced therapy medicinal products (ATMPs) – An analysis of the global regulatory status
British Journal of Clinical Pharmacology, EarlyView.Abstract Background A rapid progress in the development of advanced therapy medicinal products (ATMPs) has taken place over the past decades. The ATMPs hold great potential but face challenges in the clinical development and the regulatory process.
Allan Cramer +4 more
wiley +1 more source
International Journal of Neonatal Screening, 2019 Good information is needed to demonstrate that a screening programme is meeting its objectives, to measure performance against standards and to ensure that action is taken if standards are not met.
Catherine Coppinger, Robyn O’Loughlin
doaj +1 more source
Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor
Bulletin of the Korean Chemical Society, EarlyView.This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim +8 more
wiley +1 more source
Get screened to know your sickle cell status [PDF]
To find out whether you or your loved one has sickle cell disease (SCD) or sickle cell trait (SCT), blood tests must be done to screen for these conditions.
core
Diet of bird‐like troodontid dinosaurs: synthesis of a contentious clade
Biological Reviews, EarlyView.ABSTRACT Troodontidae is a clade of small‐to medium‐sized maniraptoran theropods that mainly lived in Laurasia (modern Asia, North America and Europe) during the Jurassic and Cretaceous periods and are believed to have had a variety of diets. The uniqueness of troodontid teeth suggests that they diverged from the typical flesh‐based diet of non‐avian ...
Yui Chi Fan +2 more
wiley +1 more source
Mediterranean Journal of Hematology and Infectious Diseases, 2015 Sickle Cell Anaemia (SCA) is the most common inherited blood disorder and is associated with severe morbidity and decreased survival. Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) is the only curative approach.
Katia Paciaroni +12 more
doaj +1 more source