Results 71 to 80 of about 105,245 (307)
Neuroimaging Biomarkers in Paediatric Sickle Cell Disease
, 2015 Sickle Cell Disease (SCD) is a collection of genetic haemoglobinopathies, the most common and severe being homozygous sickle cell anaemia. In the UK, it has been estimated that 1 in 2000 children are born with SCD. The disease is characterised by chronic
Kawadler, JM
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Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
, 2006 Over the past fifty years there has been an increase in the number of people in the UK who have a Sickle Cell Disorder (SCD) or are carriers. This increase has led to an expansion in research in this area; however one particular area that has not been ...
Millan, Jenny +2 more
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Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
Blood, 1973 Abstract A narrative concerning mass screening of a large population at risk for sickle hemolobin, glucose-6-phosphate dehydrogenase deficiency, anemia, and lead poisoning is presented. At the time of writing, more than one-tenth of a black community totaling over 104,000 individuals have been tested.
openaire +2 more sources
Food Chemistry International, EarlyView.Sanguinarine, a toxic alkaloid present in argemone, can lead to epidemic dropsy or chronic diseases through DNA intercalation and immune system suppression. Regulatory efforts face challenges due to economic motivations for adulteration as well as technical, social, and infrastructure barriers.
Gururaj Pejavara Narayana +4 more
wiley +1 more source
Frontiers in Public HealthIntroductionNewborn Screening (NBS) is a public health program designed to identify and provide early interventions for infants with genetic disorders such as Sickle Cell Disease (SCD).
Isa Hezekiah A +6 more
doaj +1 more source
Evaluation of sunn hemp performance and nutritive value in Maine, USA
Grassland Research, EarlyView.Abstract Background Sunn hemp (Crotalaria juncea L. and Crotalaria ochroleuca G. Don) was evaluated as a warm‐season legume to mitigate the “summer slump” in Maine's forage production caused by heat and moisture deficit stress. Methods This study compared three cultivars: “Crescent Sunn,” “Loei,” and “Red Mini,” at 60 and 90 days after seeding over the
Jaime Garzon, Edgar Cardenas
wiley +1 more source
Managing Chronic Pain if You Have Sickle Cell Disease [PDF]
If you have sickle cell disease (SCD), you may experience chronic pain, which is pain that lasts most days for 6 months or more. Pain management looks different for everyone.
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