Results 101 to 110 of about 78,171 (294)

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Survival Probability in Patients with Sickle Cell Anemia Using the Competitive Risk Statistical Model. [PDF]

, 2019
The clinical picture of patients with sickle cell anemia (SCA) is associated with several complications some of which could be fatal. The objective of this study is to analyze the causes of death and the effect of sex and age on survival of Brazilian ...
Ballas, Samir K., de Bragança Pereira, Basilio, de Castro Lobo, Clarisse Lopes, do Nascimento, Emilia Matos   +3 more
core   +1 more source

Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. [PDF]

, 2019
ObjectiveMicroglia play a pivotal role in the initiation and progression of Alzheimer's disease (AD). We here tested the therapeutic hypothesis that the Ca2+-activated potassium channel KCa3.1 constitutes a potential target for treating AD by reducing ...
Bushong, Trevor, Chavez, Monique, Jin, Lee-Way, Lucente, Jacopo Di, Maezawa, Izumi, Nguyen, Hai M, Singh, Latika, Singh, Vikrant, Wulff, Heike   +8 more
core   +2 more sources

Distal renal tubular acidosis in sickle cell anemia

Saudi Journal of Kidney Diseases and Transplantation, 2018
We report a rare case of two young male siblings with sickle cell anemia who presented with bilateral lower limb deformities, failure to thrive, polyuria, and polydipsia.
Anjali Bharani, Rani Manchanda, Ritesh Kumar Singh, Swati Prashant   +3 more
doaj   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Sexuality and sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia, 2013
BACKGROUND: Sickle cell disease, the most common hereditary blood disease in the world, is the result of an atypical hemoglobin called S (Hb S) which, when homozygous (Hb SS) is the cause of sickle cell anemia.
Viviane de Almeida Côbo, Cibele Alves Chapadeiro, João Batista Ribeiro, Helio Moraes-Souza, Paulo Roberto Juliano Martins   +4 more
doaj  

A Phase Ib open label, randomized, safety study of SANGUINATE™ in patients with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia
Background: Treatment of sickle cell anemia is a challenging task and despite the well understood genetic and biochemical pathway of sickle hemoglobin, current therapy continues to be limited to the symptomatic treatment of pain, supplemental oxygen ...
Hemant Misra, James Bainbridge, John Berryman, Abraham Abuchowski, Kenneth Mauricio Galvez, Luis Fernando Uribe, Angel Luis Hernandez, Nestor Rodolfo Sosa   +7 more
doaj   +1 more source

Association between hemolysis and albuminuria in adults with sickle cell anemia

Haematologica, 2012
Studies have questioned whether renal dysfunction in sickle cell disease is linked to hemolysis-associated vasculopathy. We have investigated renal function and markers of hemolysis in a cohort of 424 adult African-British patients with sickle cell ...
Thomas G. Day, Emma R. Drasar, Tony Fulford, Claire C. Sharpe, Swee Lay Thein   +4 more
doaj   +1 more source

Evaluation of the Diagnostic Accuracy of the Quantitative Point‐of‐Care SD Biosensor Standard G6PD Test for Assessment of G6PD Deficiency in Infectious Diseases

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background G6PD deficiency affects about 500 million people worldwide and is prevalent in many malaria‐endemic settings. People with G6PD deficiency are at risk of hemolysis when exposed to certain medications, including 8‐aminoquinoline drugs used to treat Plasmodium vivax malaria.
Flavia Regina Medeiros da Silva, Alexandre Gomes Vizzoni, Daniela Mendes‐de‐Almeida, Joanna Bokel, Raquel de Vasconcellos Carvalhaes de Oliveira, André Machado Siqueira, Yasmine Rangel Vieira, Simone da Costa Cruz Silva   +7 more
wiley   +1 more source

Genetic Disease Burden, Nutrition and Determinants of Tribal Health Care in Chhattisgarh State of Central-East India: A Status Paper [PDF]

, 2011
Tribal health is an important aspect of development and progress of the people. This study pertaining to genetic disease burden, nutritional status and biomedical anthropological assessment with particular reference to determinants of tribal health care ...
Balgir, RS
core   +1 more source