Results 51 to 60 of about 41,952 (292)

Sickle Cell Disease and Kidney Injury: Circulating Uromodulin Allows Early Tissue Specific Diagnosis and Monitoring of Treatment

American Journal of Hematology, EarlyView.
Ferras Alashkar, Robert Hable, Denise Zwanziger, Friederike Poppenborg, Raina Yamamoto, Hans Christian Reinhardt, Alexander Röth, Victor Herbst, Yara Bestmann, Marco Kai, Jürgen E. Scherberich   +10 more
wiley   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer. [PDF]

, 2015
BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals,
Soka, Deogratius, Harvest Mariki, Menzel, Stephan, Jeffrey C Barrett, Mariki, Harvest, Helen Rooks, Bruno Mmbando, Menzel, Stephan; id_orcid, Mmbando, Bruno, Tarjinder Singh, Stephan Menzel, Barrett, Jeffrey C., Sharon E Cox, Singh, Tarjinder, Mtatiro, Siana N, Barrett, Jeffrey C, Thein, Swee Lay, Deogratius Soka, Swee Lay Thein, Julie Makani, Mtatiro, Siana N., Siana N Mtatiro, Cox, Sharon E, Rooks, Helen, Mgaya, Josephine, Makani, Julie, Josephine Mgaya, Cox, Sharon E.   +27 more
core   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Get screened for sickle cell trait [PDF]

Know Your StatusDid you know there\u2019s more than one way to inherit Sickle Cell Disease?If you don\u2019t have a health care provider, visit our Sickle Cell Disease National Resource Directory at www.cdc.gov/ncbddd/sicklecellSickle Cell Disease ...

core   +2 more sources

Positive depression screening and associated factors among children with sickle cell anemia attending a tertiary hospital in Mwanza, Tanzania: A Cross-sectional study

Journal of Affective Disorders Reports
Background: Depression is an increasingly important public health concern among children, particularly those living with chronic illnesses, including sickle cell anemia.
Eunice H. Barnabas, Matiko Mwita, Rogatus M. Kabyemera, Emmanuela E. Ambrose   +3 more
doaj   +1 more source

Hipertensão arterial pulmonar associada à anemia falciforme Sickle cell anemia-associated pulmonary arterial hypertension

Jornal Brasileiro de Pneumologia, 2007
A hipertensão pulmonar é uma complicação comum em pacientes com anemia falciforme. A despeito das elevações leves das pressões pulmonares desses pacientes, a morbimortalidade é alta e, em pacientes adultos com anemia falciforme, a hipertensão pulmonar é ...
Roberto Ferreira Pinto Machado
doaj   +1 more source

Neuroimaging Biomarkers in Paediatric Sickle Cell Disease

, 2015
Sickle Cell Disease (SCD) is a collection of genetic haemoglobinopathies, the most common and severe being homozygous sickle cell anaemia. In the UK, it has been estimated that 1 in 2000 children are born with SCD. The disease is characterised by chronic
Kawadler, JM
core  

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

Is There a Difference in Occurrence of Complications Between Adults With Hemoglobin SS and Hemoglobin SC Disease: An Extended Systematic Review

European Journal of Haematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is characterized by both acute and chronic complications. The clinical manifestation of these complications differs between genotypes. Given the large amount of research already published, this systematic review aims to offer a complete overview of types of sickle cell complications between adults in the most common ...
Martijn van der Meer, Kim Velsink, Wing H. Tong, Jan W. Schoones   +3 more
wiley   +1 more source