Results 51 to 60 of about 2,183 (180)

Liver Cirrhosis in a Patient with Sickle Cell Trait (Hb Sβ+ Thalassemia) without Other Known Causes of Hepatic Disease

Case Reports in Gastroenterology, 2009
Liver involvement in patients with sickle cell anemia/trait includes a wide range of alterations, from mild liver function test abnormalities to cirrhosis and acute liver failure. Approximately 15–30% of patients with sickle cell anemia present cirrhosis
Luca Santi, Giancarlo Montanari, Sonia Berardi, Corrado Patti, Marta Frigerio, Claudia Sama, Paolo Caraceni, Mauro Bernardi   +7 more
doaj   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation

Clinical Pharmacology &Therapeutics, EarlyView.
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi, Kei Irie, Min Dong, Julie Ware, Russell Ware, Tomoyuki Mizuno   +5 more
wiley   +1 more source

Functional status of women with and without potentially life‐threatening maternal conditions after 6 months postpartum: A cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The aim of this study was to evaluate the impact of potentially life‐threatening maternal conditions (PLTCs) on functional disability at 6 months postpartum. Methods This prospective cohort study was done at 10 hospitals in Tigray, northern Ethiopia. A total of 1027 postpartum women (341 with PLTCs and 686 without) were enrolled into
Fitiwi Tinsae Baykemagn, Girmatsion Fisseha Abreha, Yibrah Berhe Zelelow, Alemayehu Bayray Kahsay   +3 more
wiley   +1 more source

Association between maternal pre‐pregnancy body mass index and maternal and neonatal outcomes in Saudi Arabia: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) of the mother before pregnancy and the growth of weight during pregnancy are both important perinatal health determinants. The aim of the present study was to examine the association between the maternal BMI and obstetric and ...
Randa Elsayed, Eman Al Ali, Rawabi AlAbdulgader, Shouq ALshuwayfie, Hasna Almutawa, Zahra Alhawaj, Bayan Albesher, Fatimah Almuaybid   +7 more
wiley   +1 more source

Hipertensão arterial pulmonar associada à anemia falciforme Sickle cell anemia-associated pulmonary arterial hypertension

Jornal Brasileiro de Pneumologia, 2007
A hipertensão pulmonar é uma complicação comum em pacientes com anemia falciforme. A despeito das elevações leves das pressões pulmonares desses pacientes, a morbimortalidade é alta e, em pacientes adultos com anemia falciforme, a hipertensão pulmonar é ...
Roberto Ferreira Pinto Machado
doaj   +1 more source

Fetal growth trajectories and neonatal outcomes: A French population‐based study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study assesses whether fetal growth trajectories are associated with neonatal outcomes. Methods The study population included 8537 singleton liveborn infants from the 2021 French National Perinatal Survey. Fetal growth trajectories were assessed between second and third trimester routine ultrasounds and between the third ...
Pierre Gibert, Alice Hocquette, Camille Le Ray, Jennifer Zeitlin, Isabelle Monier, Anne Ego, ENP2021 Study Group, Camille Le Ray, Nathalie Lelong, Hélène Cinelli, Béatrice Blondel, Nolwenn Regnault, Virginie Demiguel, Elodie Lebreton, Benoit Salanave, Jeanne Fresson, Annick Vilain, Thomas Deroyon, Philippe Raynaud, Sylvie Rey, Khadoudja Chemlal, Nathalie Rabier‐Thoreau, Frédérique Collombet‐Migeon   +22 more
wiley   +1 more source

Radiologic Evaluation of Paranasal Sinuses in Sickle Cell Anemia and Thalassemia: Case–Control Study

Laryngoscope Investigative Otolaryngology
Background Sickle cell disease and thalassemia are inherited hematological disorders that are common worldwide. These patients suffer from chronic hemolytic anemia, which can result in bone marrow dysfunction and, in rare cases, extramedullary ...
Maha A. Alharbi, Ayat AlDarwish, Reem M. Alamier, Nawal E. Omer, Mahmoud A. Alabbad, Abdulmohsin M. Aljassem, Qasem M. ALalwan, Danah H. Althomaly, Hussain Abdullali Albaharna   +8 more
doaj   +1 more source

Positive depression screening and associated factors among children with sickle cell anemia attending a tertiary hospital in Mwanza, Tanzania: A Cross-sectional study

Journal of Affective Disorders Reports
Background: Depression is an increasingly important public health concern among children, particularly those living with chronic illnesses, including sickle cell anemia.
Eunice H. Barnabas, Matiko Mwita, Rogatus M. Kabyemera, Emmanuela E. Ambrose   +3 more
doaj   +1 more source

Subtotal Versus Total Splenectomy in Children With Sickle Cell Disease: Clinical Outcomes and Splenic Function Assessed by Pocked Red Blood Cell Count

American Journal of Hematology, EarlyView.
Alma Al Sibaaie, Abdoulaye Sissoko, Carmen Capito, Christophe Chardot, Mariane de Montalembert, Valentine Brousse, Joséphine Brice, Martina Bevacqua, Camille Roussel, Lucie Dumas, Astan Cissé, Pierre Buffet, Slimane Allali   +12 more
wiley   +1 more source