Results 51 to 60 of about 216,468 (292)

The Virginia Sickle Cell Anemia Awareness Program: Education, Screening, and Counseling [PDF]

, 1977
In 1968, a program of screening for sickle trait carriers was begun as part of the work of the Hematology Division, Department of Medicine, at the Medical College of Virginia.
Cooper, Florence N., Scott, Robert B.
core   +1 more source

Coexisting Sickle Cell Anemia and Sarcoidosis: A Management Conundrum! [PDF]

, 2017
Sickle cell disease and Sarcoidosis are conditions that are more common in the African American population. In this report we share an unfortunate patient who had hepatic sarcoidosis but could not receive steroids since that precipitated acute liver ...
Gollahalli, Nagesh S., Nutan, FNU
core   +3 more sources

Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia. [PDF]

PLoS ONE, 2013
The six-minute walk test is a well-established submaximal exercise reflecting the functional status and the clinical severity of sickle cell patients. The aim of the present cross-sectional study was to investigate the biological determinants of the six ...
Xavier Waltz, Marc Romana, Marie-Dominique Hardy-Dessources, Yann Lamarre, Lydia Divialle-Doumdo, Marie Petras, Vanessa Tarer, Régine Hierso, Kizzy-Clara Baltyde, Benoît Tressières, Marie-Laure Lalanne-Mistrih, Fréderic Maillard, Olivier Hue, Maryse Etienne-Julan, Philippe Connes   +14 more
doaj   +1 more source

Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease [PDF]

, 2017
Key Points Regadenoson did not reduce iNKT cell activation to a prespecified level when administered to patients with SCD. Because iNKT cell activation was not reduced, the benefit of iNKT cell-based therapies in SCD cannot be determined.
Achebe, Maureen, Chu, Hillary, Field, Joshua J., George, Alex, Gordeuk, Victor R., Gowhari, Michel, Heeney, Matthew M., Hoppe, Carolyn, Lin, Gene, Linden, Joel, Majerus, Elaine, Nathan, David G., Neuberg, Donna, Puligandla, Maneka, Sheehan, Brian   +14 more
core   +2 more sources

Not all red cells sickle the same: Contributions of the reticulocyte to disease pathology in sickle cell anemia.

Blood reviews, 2019
Sickle cell anemia (SCA) is associated with morbidity and early death. While the switch from fetal to sickle hemoglobin during the first months of life results in hemolytic anemia with reticulocytosis, the role of the reticulocyte in the pathophysiology ...
Marcus A. Carden, R. Fasano, E. Meier
semanticscholar   +1 more source

The Longitudinal Effect of APOL1 Risk Alleles on Sickle Cell Anemia‐Associated Kidney Function

American Journal of Hematology, EarlyView.
ABSTRACT Progressive kidney injury is a major cause of morbidity and mortality in sickle cell anemia (SCA). The high risk APOL1 G1/G2 variants contribute to the development of kidney disease in individuals of African ancestry, including those with SCA.
Sara R. Rashkin, Guolian Kang, Clifford M. Takemoto, Mitchell J. Weiss, Kenneth I. Ataga, Santosh L. Saraf, Jeffrey Lebensburger, Rima S. Zahr   +7 more
wiley   +1 more source

Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia

Revista Brasileira de Hematologia e Hemoterapia, 2015
BACKGROUND: Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysiology of sickle cell anemia. The expression of cytokines is regulated by genetic mechanisms however the effect of haptoglobin polymorphisms on these cytokines is not
Bruna Spinella Pierrot-Gallo, Perla Vicari, Sandra Satiko Matsuda, Samuel Ademola Adegoke, Grazielle Mecabo, Maria Stella Figueiredo   +5 more
doaj   +1 more source

Sickle cell trait and risk of cognitive impairment in African-Americans: The REGARDS cohort [PDF]

, 2019
Background: Sickle cell anemia may be associated with cognitive dysfunction, and some complications of sickle cell anemia might affect those with sickle cell trait (SCT), so we hypothesized that SCT is a risk factor for cognitive impairment. Methods:
Cahill, Christina R., Cushman, Mary, Hyacinth, Hyacinth I., Irvin, Marguerite Ryan, Judd, Suzanne E., Leach, Justin M., Manly, Jennifer, McClure, Leslie A., Naik, Rakhi, Unverzagt, Frederick, Wadley, Virginia G., Winkler, Cheryl, Zakai, Neil A.   +12 more
core   +1 more source

The clinical epidemiology of sickle cell anemia In Africa

American journal of hematology/oncology, 2017
Sickle cell anemia (SCA) is the commonest severe monogenic disorders of humans. The disease has been highly characterized in high‐income countries but not in sub‐Saharan Africa where SCA is most prevalent. We conducted a retrospective cohort study of all
A. Macharia, G. Mochamah, S. Uyoga, Carolyne M. Ndila, G. Nyutu, J. Makale, Metrine Tendwa, E. Nyatichi, J. Ojal, M. Shebe, Kennedy O. Awuondo, N. Mturi, N. Peshu, Benjamin Tsofa, J. Scott, K. Maitland, T. Williams   +16 more
semanticscholar   +1 more source

Relationship between pulmonary and cardiac abnormalities in sickle cell disease: implications for the management of patients

Revista Brasileira de Hematologia e Hemoterapia, 2016
Objective: To evaluate the association between clinical, pulmonary, and cardiovascular findings in patients with sickle cell disease and, secondarily, to compare these findings between sickle cell anemia patients and those with other sickle cell diseases.
Maria Christina Paixão Maioli, Andrea Ribeiro Soares, Ricardo Bedirian, Ursula David Alves, Cirlene de Lima Marinho, Agnaldo José Lopes   +5 more
doaj   +1 more source