Results 41 to 50 of about 28,352 (224)
Environmental and Molecular Mutagenesis, EarlyView.Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons +17 more
wiley +1 more source
The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]
, 2020 Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core +1 more source
Advances in Double‐Stranded DNA Targeting Technologies
Exploration, EarlyView.Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Zuhao Shen +8 more
wiley +1 more source
Sickle cells and sickle trait in thrombosis [PDF]
Blood, 2019 The blood cells form a beautiful and elegant system. For a century, hematologists have comfortably understood that each type of blood cell has its own independent function in immunity, hemostasis, or oxygen transport, but in this issue of Blood, Faes and colleagues show that nature is far more efficient than that.
openaire +2 more sources
Reaching Community Through School Going Children for Sickle Cell Disease in Zankhvav Village of Surat District, Western India [PDF]
, 2012 Objectives: The objective of the study was to explore a method to reach the community via school going adolescents for screening tribal people for Sickle Cell disease.
Bansal, R +4 more
core +1 more source
Quantitative sensory testing in children with sickle cell disease: additional insights and future possibilities. [PDF]
, 2019 Quantitative sensory testing (QST) is used in a variety of pain disorders to characterize pain and predict prognosis and response to specific therapies.
Brown, Dawn S. +9 more
core +2 more sources
The epidemiology of chronic kidney disease (CKD) in rural East Africa: A population-based study. [PDF]
, 2020 BackgroundChronic kidney disease (CKD) may be common among individuals living in sub-Saharan Africa due to the confluence of CKD risk factors and genetic predisposition.MethodsWe ascertained the prevalence of CKD and its risk factors among a sample of 3 ...
Atukunda, Mucunguzi +14 more
core +2 more sources
Online decision aids for contraceptive choices in women with chronic conditions: A systematic review
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Background Women with chronic conditions face increased risks of unintended pregnancy and adverse maternal and perinatal outcomes. Tailored, online contraceptive decision aids might improve informed decision‐making and support reproductive health by promoting patient‐centered care in this population.
Begashaw Melaku Gebresillassie +2 more
wiley +1 more source
BMC Research Notes, 2019 Objective It is estimated that 50% to 90% of infants born with (SCA) in sub-Saharan Africa die before 5 years old. Northern Darfur State at western Sudan region has a multiethnic population with a high frequency of sickle cell anaemia, but little about ...
Mudathir A. Adam +2 more
doaj +1 more source
Journal of Community Hospital Internal Medicine Perspectives, 2021 In this report, we present a 29-year-old African American female who was brought to a local emergency department after being found unresponsive by her mother.
Ava Runge, Danielle Brazel, Zahra Pakbaz
doaj +1 more source