Results 51 to 60 of about 40,607 (289)

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Isotopic niche variation in Tasmanian devils Sarcophilus harrisii with progression of devil facial tumor disease

Ecology and Evolution, 2021
Devil facial tumor disease (DFTD) is a transmissible cancer affecting Tasmanian devils Sarcophilus harrisii. The disease has caused severe population declines and is associated with demographic and behavioral changes, including earlier breeding, younger ...
Olivia Bell, Menna E. Jones, Calum X. Cunningham, Manuel Ruiz‐Aravena, David G. Hamilton, Sebastien Comte, Rodrigo K. Hamede, Stuart Bearhop, Robbie A. McDonald   +8 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice

Mediators of Inflammation, 2013
Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these
Steven Biesmans, Theo F. Meert, Jan A. Bouwknecht, Paul D. Acton, Nima Davoodi, Patrick De Haes, Jacobine Kuijlaars, Xavier Langlois, Liam J. R. Matthews, Luc Ver Donck, Niels Hellings, Rony Nuydens   +11 more
doaj   +1 more source

Long-term absenteeism due to sickness in Sweden. How long does it take and what happens after?

, 2007
Long-term sickness, Returns to work, Full and partial disability, Competing-risks model, Multinomial-logit model, I12, J21, J28,
Daniela Andrén, Andrén, Daniela,, Andrén, Daniela   +2 more
core   +1 more source

Cinerama sickness and postural instability [PDF]

, 2013
Motion sickness symptoms and increased postural instability induced by motion pictures have been reported in a laboratory, but not in a real cinema. We, therefore, carried out an observational study recording sickness severity and postural instability in
Lubeck, A.J.A., Bos, J.E.; id_orcid, Ledegang, W.D., Bos, J.E., Stins, J.F., Stins, J.F.; id_orcid   +5 more
core   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior

Journal of Neuroinflammation, 2011
Background Interleukin (IL)-6 is produced in the brain during peripheral infection and plays an important but poorly understood role in sickness behavior.
Johnson Rodney W, Sparkman Nathan L, Burton Michael D   +2 more
doaj   +1 more source

Change in sickness behavior assessed with the Sickness Questionnaire after endotoxin challenge is associated with the degree of change in inflammatory cytokines

, 2017
The Sickness Questionnaire is a newly developed questionnaire for self-reported sickness behavior in humans. Here, we determined the time-course of sickness behavior and the association with changes in cytokine levels in an experimental study where 22 ...
B. Karshikoff, Olsson, MJ, M. Lekander, Andreasson, A, Lekander, M,, Karshikoff, B,, J. Axelsson, Lasselin, J, Axelsson, J, J. Lasselin, A. Andreasson, M.J. Olsson   +11 more
core   +1 more source