Results 71 to 80 of about 194,696 (295)

Automated home-cage monitoring as a potential measure of sickness behaviors and pain-like behaviors in LPS-treated mice.

PLoS ONE, 2021
The use of endotoxin, such as lipopolysaccharide (LPS) as a model of sickness behavior, has attracted recent attention. To objectively investigate sickness behavior along with its pain-like behaviors in LPS-treated mice, the behavioral measurement ...
Hasriadi, Peththa Wadu Dasuni Wasana, Opa Vajragupta, Pornchai Rojsitthisak, Pasarapa Towiwat   +4 more
doaj   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Fear-Avoidance Behavior and Sickness Absence in Patients with Work-Related Musculoskeletal Disorders

Medicina, 2020
(1) Background and objectives: The purpose of this work is to determine the association of fear-avoidance attitudes with sickness absence status, its duration and disability in a work accident context.
Israel Macías-Toronjo, José L. Sánchez-Ramos, María J. Rojas-Ocaña, Esperanza Begoña García-Navarro   +3 more
doaj   +1 more source

Economic incentives and long-term sickness absence: The indirect effect of replacement rates on absence behavior [PDF]

, 2015
Reductions in SI replacement levels has been a widely used instrument to lower sickness absence rates. The idea is that increasing the direct cost of absence would lower the absence rate.
Nilsson, Martin
core  

Motion sickness in automated vehicles with forward and rearward facing seating orientations [PDF]

, 2019
Automated vehicles (AV’s) offer greater flexibility in cabin design particularly in a future where no physical driving controls are required. One common concept for an automated vehicle is to have both forward and rearward facing seats.
Allen, Bos, BS6841, Cyriel Diels, Diels, Diels, Diels, Donohew, Doug Thake, Ebenholtz, Eost, Feenstra, Golding, Griffin, Griffin, Griffin, Han, Kabal, Kennedy, Kennedy, Keshavarz, Kuiper, Lawther, MacKenzie, Mansfield, McCauley, Murphy, Narayanamoorthy, Ohyama, Paul Herriotts, Ramaswami, Reason, Riccio, Rolnick, Singleton, Sivak, Spencer Salter, St-Louis, Stratis Kanarachos, Sundström, Turner, Turner, Wada, Wada, Wada, Yokota   +45 more
core   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Reduction of voluntary physical activity in mice induced by toll-like receptor 7 agonist R-848

Journal of Physical Fitness and Sports Medicine, 2018
The behavioral response of mice to infection is often demonstrated by a reduction in physical activity. Although it is known that single-stranded (ss) RNA, one of the genomes found in viruses, activates to produce type I interferon (IFNs) and pro ...
Eri Oyanagi, Masataka Uchida, Michael J. Kremenik, Hiromi Yano   +3 more
doaj   +1 more source

Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

Journal of Neuroinflammation, 2020
Background Recently, depression has been identified as a prevalent and severe mental disorder. However, the mechanisms underlying the depression risk remain elusive.
Hetao Bian, Gaohua Wang, Junjie Huang, Liang Liang, Yage Zheng, Yanyan Wei, Hui Wang, Ling Xiao, Huiling Wang   +8 more
doaj   +1 more source