Results 161 to 170 of about 1,561,917 (189)

Amidination of Lysine Side Chains

ChemInform, 1996
AbstractFor Abstract see ChemInform Abstract in Full Text.
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Engineered Ionizable Side Chains

2015
One of the great challenges of mechanistic ion-channel biology is to obtain structural information from well-defined functional states. In the case of neurotransmitter-gated ion channels, the open-channel conformation is particularly elusive owing to its transient nature and brief mean lifetime.
Gisela D. Cymes, Claudio Grosman
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Energy Matrix of Structurally Important Side-Chain/Side-Chain Interactions in Proteins

Journal of Chemical Theory and Computation, 2010
The interactions between amino acid side chains in proteins are generally considered to be the most important stabilizing factor controlling the precise arrangement of the polypeptide chain into a well-defined spatial structure. We used the RI-DFT-D method to calculate the full 20 × 20 matrix of interaction energies between all pairs of amino acid side
Karel Berka, Jiří Vondrášek, Pavel Hobza, Roman A. Laskowski   +3 more
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Protein side-chain acetylations

1984
Publisher Summary This chapter discusses the acetylation of protein side-chains. Using preparative gel electrophoresis, it is now possible to prepare the well-defined histone substrates necessary for the studies of the kinetics and mode of action of isolated transacetylases or deacetylases.
Richard Sterner, Eugene A. Di Paola, Vincent G. Allfrey   +2 more
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Modeling side-chain conformation

Current Opinion in Structural Biology, 1996
Over the past few years, a number of methods for the calculation of side-chain conformations in proteins have been described. More recent studies have considered the effect of combinatorial packing, derivations from idealized rotameric structures and, to a limited extent, backbone flexibility on the quality and efficiency of calculations of protein ...
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Discretization orders for protein side chains

Journal of Global Optimization, 2014
Proteins are important molecules that are widely studied in biology. Since their three-dimensional conformations can give clues about their function, an optimal methodology for the identification of such conformations has been researched for many years. Experiments of Nuclear Magnetic Resonance (NMR) are able to estimate distances between some pairs of
Costa, Virginia, Mucherino, Antonio, Lavor, Carlile, Cassioli, Andrea, Carvalho, Luiz Mariano, Maculan, Nelson   +5 more
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Heteroaromatic side-chain analogs of pregabalin

Bioorganic & Medicinal Chemistry Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Po-Wai Yuen, Schelkun Robert Michael, David J. Wustrow, Mark G. Vartanian, Ti-Zhi Su, Jack J. Kinsora   +5 more
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Mutual orientation of main chains and side chains in nematic liquid-crystalline side-chain polysiloxanes

Macromolecular Chemistry and Physics, 1999
The orientation of main-chain segments of some polysiloxanes containing mesogenic side groups was estimated by 29 Si NMR under high-power proton decoupling. The second-order orientation degree related to the orientation distribution of chemical shift tensors was calculated from the spectra.
Wolfgang Weissflog, Andrea Jacobi, Marion Griebel, Günter Hempel, Detlef Reichert   +4 more
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Synthesis of Paullones with Aminoalkyl Side Chains

Archiv der Pharmazie, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Daniel W. Zaharevitz, Laurent Meijer, Maryse Leost, Karen Wieking, Conrad Kunick, Marie Knockaert   +5 more
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Potent side‐chain to side‐chain cyclized dermorphin analogues containing a carbonyl bridge

Journal of Peptide Science, 2003
AbstractA new family of cyclic opioid peptide analogues related to the 1–4 sequence of dermorphin/deltorphin (Tyr‐D‐Aaa2‐Phe‐Aaa4‐NH2) has been synthesized. The synthesis of the linear precursor peptides was accomplished by the solid‐phase method and ring formation was achieved via a ureido group incorporating the side chain amino functions of D‐Aaa2 ...
Danuta Pawlak, Jan Izdebski, Marta Oleszczuk, Nga N. Chung, Peter W. Schiller, Jacek Wójcik, Katarzyna Filip   +6 more
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