Results 261 to 270 of about 781,607 (313)

Tuneable Side-Chain Supramolecular Polymer

Organic Letters, 2007
[reaction: see text] A random copolymer containing 1,5-dialkyloxynaphthalene moieties has been synthesized using atom-transfer radical polymerization. We have shown that this polymer has the ability to form complexes with the tetracationic cyclophane cyclobis(paraquat-p-phenylene) (CBPQT(4+)) and that electrochemical reduction of the cyclophane or the ...
Graeme, Cooke, James F, Garety, Shanika Gunatilaka, Hewage, Brian J, Jordan, Gouher, Rabani, Vincent M, Rotello, Patrice, Woisel   +6 more
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Side-chain–side-chain interactions and stability of the helical state

Physical Review E, 2014
Understanding the driving forces that lead to the stability of the secondary motifs found in proteins, namely α-helix and β-sheet, is a major goal in structural biology. The thermodynamic stability of these repetitive units is a result of a delicate balance between many factors, which in addition to the peptide chain involves also the solvent.
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Energy Matrix of Structurally Important Side-Chain/Side-Chain Interactions in Proteins

Journal of Chemical Theory and Computation, 2010
The interactions between amino acid side chains in proteins are generally considered to be the most important stabilizing factor controlling the precise arrangement of the polypeptide chain into a well-defined spatial structure. We used the RI-DFT-D method to calculate the full 20 × 20 matrix of interaction energies between all pairs of amino acid side
Karel, Berka, Roman A, Laskowski, Pavel, Hobza, Jiří, Vondrášek   +3 more
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The ST pinch: A side chain‐to‐side chain hydrogen‐bonded motif

Proteins: Structure, Function, and Bioinformatics, 2012
AbstractThe ST Pinch is a 12‐membered hydrogen‐bonded motif (Ser/Thr‐Xaa‐Ser/Thr) involving the side chain oxygen atoms of two Ser/Thr residues. We identified the ST Pinch in 104 proteins in a database containing high‐resolution crystal structures. Conformational analysis of the ST Pinch in these proteins points to specific preferences for the Xaa ...
Martha G, Bomar, Upadhyayula S, Raghavender, Alexander W I, Spindel, Krishna, Kodukula, Amit K, Galande   +4 more
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Potent side‐chain to side‐chain cyclized dermorphin analogues containing a carbonyl bridge

Journal of Peptide Science, 2003
AbstractA new family of cyclic opioid peptide analogues related to the 1–4 sequence of dermorphin/deltorphin (Tyr‐D‐Aaa2‐Phe‐Aaa4‐NH2) has been synthesized. The synthesis of the linear precursor peptides was accomplished by the solid‐phase method and ring formation was achieved via a ureido group incorporating the side chain amino functions of D‐Aaa2 ...
Katarzyna, Filip, Marta, Oleszczuk, Danuta, Pawlak, Jacek, Wojcik, Nga N, Chung, Peter W, Schillerc, Jan, Izdebski   +6 more
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Side-Chain-Induced Rigid Backbone Organization of Polymer Semiconductors through Semifluoroalkyl Side Chains

Journal of the American Chemical Society, 2016
While high-mobility p-type conjugated polymers have been widely reported, high-mobility n-type conjugated polymers are still rare. In the present work, we designed semifluorinated alkyl side chains and introduced them into naphthalene diimide-based polymers (PNDIF-T2 and PNDIF-TVT).
Kang, B, Kim, R, Lee, SB, Kwon, SK, Kim, YH, CHO, KIL WON   +5 more
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Chymotrypsin inhibitory conformation of dipeptides constructed by side chain–side chain hydrophobic interactions

Journal of Molecular Recognition, 1993
AbstractA complete series of configurationally isomers (L‐L, L‐D, D‐L AND D‐D) of a dipeptide Leu‐Phe benzyl ester have been synthesized and assayed for chymotrypsin. In the conformational analysis by 400 MMz 1H NMR, the L‐D and D‐L isomers, but not hte L‐L and D‐D isomers, showed fairly large up field shifts (0.2–0.4 ppm) of Leu‐βCH2 and γCH proton ...
H, Sakamoto, Y, Shimohigashi, I, Maeda, T, Nose, K, Nakashima, I, Nakamura, T, Ogawa, K, Kawano, M, Ohno   +8 more
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Addition of side chains to a known backbone with defined side-chain centroids

Biophysical Chemistry, 2002
An automatic procedure is proposed for adding side chains to a protein backbone; it is based on optimization of a simplified energy function for peptide side chains, given its backbone and positions of side-chain centroids. The energy is expressed as a sum of the energies of interaction between side chains, and a harmonic penalty function accounting ...
Rajmund, Kaźmierkiewicz, Adam, Liwo, Harold A, Scheraga   +2 more
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Activity profiles of novel side-chain to side-chain cyclized opioid peptide analogs

Neuropeptides, 1984
A new family of opioid peptide analogs cyclized through amide bond formation between side-chain amino and carboxyl groups was tested in mu- and delta-opioid receptor selective bio- and binding assays. Within the series of compounds investigated considerable variation in potency and receptor selectivity was observed as a consequence of the introduced ...
P W, Schiller, T M, Nguyen
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Cephalosporin Side Chain Cross-reactivity

The Journal of Allergy and Clinical Immunology: In Practice, 2015
I have a 4-year-old boy with a history of urticaria and angioedema to both penicillin and Suprax (cefixime). A skin test is negative to Pre-Pen and penicillin G. He is scheduled for a cautious oral challenge to penicillin. My question is: what are the other cephalosporins to which I can challenge him that have nonidentical R-group side chains to those ...
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