Side-chain conformational changes upon protein-protein association [PDF]
, 2010 Conformational changes upon protein-protein association are the key element of the binding mechanism. The study presents a systematic large-scale analysis of such conformational changes in the side chains.
Kirys, Tatsiana +3 more
core +2 more sources
Free radical 5-exo-dig cyclization as the key step in the synthesis of bis-butyrolactone natural products: experimental and theoretical studies [PDF]
, 2011 Radical cyclization reactions were performed by 5-exo-dig mode to yield cis-fused bicyclic systems, leading to the synthesis of bis-butyrolactone class of natural products.
Allinger +23 more
core +1 more source
A blockchain architecture with master-slave blockchain
物联网学报, 2021 With the continuous development of blockchain technology, different chains are derived due to different adaptation scenarios.Each chain has its own characteristics, such as public chains like bitcoin and ethereum, a large number of private chains and ...
Pengliu TAN, Lixuran WAN
doaj
MoleculesPorous aromatic frameworks (PAFs) are an auspicious class of materials that allow for the introduction of sulfonic acid groups at the aromatic core units by post-synthetic modification. This makes PAFs promising for proton-exchange materials.
Simon F. Winterstein +4 more
doaj +1 more source
Side Chain-Modified Benzothiazinone Derivatives with Anti-Mycobacterial Activity
Biomedicines, 2023 Tuberculosis (TB) is a leading infectious disease with serious antibiotic resistance. The benzothiazinone (BTZ) scaffold PBTZ169 kills Mycobacterium tuberculosis (Mtb) through the inhibition of the essential cell wall enzyme decaprenylphosphoryl-β-D ...
Dongguang Fan +12 more
doaj +1 more source
Too packed to change: side-chain packing and site-specific substitution rates in protein evolution [PDF]
PeerJ, 2015 In protein evolution, due to functional and biophysical constraints, the rates of amino acid substitution differ from site to site. Among the best predictors of site-specific rates are solvent accessibility and packing density.
María Laura Marcos, Julian Echave
doaj +2 more sources
Ligand recognition by 14‐3‐3 proteins requires negative charges but not necessarily phosphorylation
FEBS Letters, Volume 599, Issue 6, Page 838-847, March 2025.Interactions of 14‐3‐3 proteins with their binding partners are attributed to phosphorylation of the binding partners. In this work, we show that at least one negative charge is required for the peptides to bind 14‐3‐3ε, although phosphorylation is not necessary, and that two negative charges are preferable for high affinity binding.
Seraphine Kamayirese +2 more
wiley +1 more source
Synthesis and characterisation of controllably functionalised polyaniline nanofibres [PDF]
, 2009 A novel method for functionalising solution based polyaniline (PAni) nanofibres is reported whereby the degree of side-chain attachment can be controllably altered.
Acevedo +49 more
core +1 more source
Folding in lattice models with side chains [PDF]
Comput. Phys. Commun. 147(1-2), 625 (2002), 2002 The folding kinetics of three-dimensional lattice Go models with side chains is studied using two different Monte Carlo move sets. A flexible move set based on single, double and triple backbone moves is found to be far superior compared to the standard Monte Carlo dynamics.
arxiv +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source