Results 61 to 70 of about 7,119,113 (404)
Synthesis of 1 alpha,25-Dihydroxyvitamin D Analogues Featuring a S-2-symmetric CD-ring Core [PDF]
, 2009 Three analogues of 1 alpha,25-dihydroxyvitamin D-3 (calcitriol), featuring a transfused decalin C, D-core with local S-2-symmetry, and possessing identical side-chain and seco-B,A-ring structures, have been synthesized starting from readily available ...
De Clercq, Pierre, Minne, Garrett
core +2 more sources
Side chain flexibility and the symmetry of protein homodimers.
PLoS ONE, 2020 A comprehensive analysis of crystallographic data of 565 high-resolution protein homodimers comprised of over 250,000 residues suggests that amino acids form two groups that differ in their tendency to distort or symmetrize the structure of protein ...
Yaffa Shalit, Inbal Tuvi-Arad
doaj +1 more source
A model of dynamic side‐chain–side‐chain interactions in the α‐lactalbumin molten globule [PDF]
Protein Science, 2001 AbstractProteins in the molten globule state contain high levels of secondary structure, as well as a rudimentary, nativelike tertiary topology. Thus, the structural similarity between the molten globule and native proteins may have a significant bearing in understanding the protein‐folding problem.
Ping Bai +3 more
openaire +2 more sources
FEBS Letters, Volume 599, Issue 6, Page 901-911, March 2025.The human Na+/H+ antiporter NHA2 transports Na+ or Li+ in exchange for protons across cell membranes, and its dysfunction results in various pathologies, e.g., fertility disorders, hypertension, or diabetes. This work provides the molecular characterization of interactions of NHA2 with its specific inhibitor phloretin, which can be helpful for the ...
Olga Zimmermannova +3 more
wiley +1 more source
Unifying model of driven polymer translocation [PDF]
, 2012 We present a Brownian dynamics model of driven polymer translocation, in which non-equilibrium memory effects arising from tension propagation (TP) along the cis side subchain are incorporated as a time-dependent friction. To solve the effective friction,
A. Bhattacharya +5 more
core +3 more sources
Investigation of a side‐chain‐side‐chain hydrogen bond by mutagenesis, thermodynamics, and NMR spectroscopy [PDF]
Protein Science, 1995 AbstractAnomalous NMR behavior of the hydroxyl proton resonance for Ser 31 has been reported for histidine‐containing protein (HPr) from two microorganisms: Escherichia coli and Staphylococcus aureus. The unusual slow exchange and chemical shift exhibited by the resonance led to the proposal that the hydroxyl group is involved in a strong hydrogen bond.
J W Anderson +4 more
openaire +3 more sources
FEBS Letters, Volume 599, Issue 7, Page 952-970, April 2025.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source
Mechanically bonded macromolecules [PDF]
, 2010 Mechanically bonded macromolecules constitute a class of challenging synthetic targets in polymer science. The controllable intramolecular motions of mechanical bonds, in combination with the processability and useful physical and mechanical properties ...
Benítez, Diego +5 more
core +1 more source
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin
Marine Drugs, 2013 Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as “head-to-side-chain” cyclodepsipeptides, have been isolated and characterized.
Marta Pelay-Gimeno +2 more
doaj +1 more source
The Annals of Probability, 1986 Let $S$ be a countable set, and $a, b$ two distinct elements not in $S$. Let $\Omega$ be the set of functions $\omega: Z$ (integers) $\rightarrow S \cup \{a, b\}$ so that (i) $\omega (n) \in S$ for some $n$, (ii) $\omega (n) = a \Rightarrow \omega(m) = a$ for $m n$. On $\Omega$, let $x(n)$ be the $n$th coordinate, $\theta_n$ the shift operator, and $\
openaire +2 more sources