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Cefiderocol: A Siderophore Cephalosporin
Annals of Pharmacotherapy, 2020Objective: This article reviews the available data on the chemistry, spectrum of activity, pharmacokinetic and pharmacodynamic properties, clinical efficacy, and potential place in therapy of cefiderocol. Data Sources: A literature search through PubMed, Google Scholar, and ClinicalTrials.gov was conducted (2009 to March 2020) using the search terms ...
Rania M. El-Lababidi, John George Rizk
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Siderophore production by actinobacteria
BioMetals, 2014Produced by bacteria, fungi and plants, siderophores are low-molecular-weight chelating agents (200-2,000 Da) to facilitate uptake of iron (Fe). They play an important role in extracellular Fe solubilization from minerals to make it available to microorganisms.
Wenfeng, Wang +3 more
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Tobacco-borne siderophoric activity
Archives of Biochemistry and Biophysics, 1989The proinflammatory and carcinogenic effects of cigarette smoking are well known. Recent evidence indicts iron as a powerful promoter of inflammatory processes and, perhaps not coincidentally, the lungs and alveolar macrophages of smokers contain abnormally large amounts of iron.
M W, Qian, J W, Eaton
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BioMetals, 2009
Siderophores are low molecular weight organic ligands exuded by some aerobic organisms and plants to acquire Fe under Fe-limited conditions. The hydroxamate siderophores may sorb to aluminosilicate clays through a variety of mechanisms depending upon the nature of the clay and of the siderophore along with solution conditions such as pH, ionic strength,
Patricia A, Maurice +2 more
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Siderophores are low molecular weight organic ligands exuded by some aerobic organisms and plants to acquire Fe under Fe-limited conditions. The hydroxamate siderophores may sorb to aluminosilicate clays through a variety of mechanisms depending upon the nature of the clay and of the siderophore along with solution conditions such as pH, ionic strength,
Patricia A, Maurice +2 more
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Bacterial siderophores promote plant growth: Screening of catechol and hydroxamate siderophores
International Journal of Phytoremediation, 2017The aim of the study was to determine the quality and quantity of siderophores produced by bacteria isolated from plants' roots. The second aim was to determine the effect of siderophores on plants growth (Festuca rubra L. and Brassica napus L.). The study was carried out using bacteria isolated from roots of: Arabidopsis thaliana L., F.
Anna, Grobelak, Joanna, Hiller
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ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
E.A. Dertz, K.N. Raymond
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AbstractFor Abstract see ChemInform Abstract in Full Text.
E.A. Dertz, K.N. Raymond
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Microbial siderophore-mediated transport
Biochemical Society Transactions, 2002Microbial iron chelates, called siderophores, are synthesized by bacteria and fungi in response to low iron availability in the environment. The present review summarizes structural details of siderophore ligands with respect to their transport properties.
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Recent advances in siderophore biosynthesis
Current Opinion in Chemical Biology, 2009The biosynthesis of the microbial small molecule iron scavengers known as siderophores has been of interest since their discovery in the middle of the past century. Two main pathways for siderophore biosynthesis exist. One is directed by a large family of modular multienzymes called non-ribosomal peptide synthetases (NRPSs) while the other is NRPS ...
Barry, Sarah M., Challis, Gregory L.
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EcoSal Plus
ABSTRACT Siderophore cephalosporins are designed to exploit bacterial nutrient uptake systems to gain accelerated uptake across the outer membrane of Gram-negative bacteria. They contain iron (III) binding motifs that allow them to form complexes that will be recognized as potential substrates by iron-siderophore ...
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ABSTRACT Siderophore cephalosporins are designed to exploit bacterial nutrient uptake systems to gain accelerated uptake across the outer membrane of Gram-negative bacteria. They contain iron (III) binding motifs that allow them to form complexes that will be recognized as potential substrates by iron-siderophore ...
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Siderophore-dependent ferrichelatases
Iron is a crucial secondary metabolite for bacterial proliferation, but its bioavailability under infection conditions is limited by the low solubility of ferric ion and the host's ability to sequester iron by protein chelation. In these iron limiting conditions, bacteria produce and secrete low molecular weight ferric ion chelators, siderophores, to ...C E, Merrick +2 more
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