Results 101 to 110 of about 25,644,253 (316)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

P-proteins in Arabidopsis are heteromeric structures involved in rapid sieve tube sealing

Frontiers in Plant Science, 2013
Structural phloem proteins (P-proteins) are characteristic components of the sieve elements in all dicotyledonous and many monocotyledonous angiosperms.
Stephan B Jekat, Antonia M Ernst, Andreas evon Bohl, Sascia eZielonka, Richard M Twyman, Gundula A Noll, Dirk ePrüfer   +6 more
doaj   +1 more source

Analysis of sorbents and catalysts used during a 90-day manned test [PDF]

Chemical analysis of organic trace contaminants in simulated space station atmospheres desorbed from molecular sieve, silicon gel, and catalyst ...
Lucero, A. S., Mader, P. P.
core   +1 more source

Sieve analysis to understand how SARS-CoV-2 diversity can impact vaccine protection. [PDF]

PLoS Pathog, 2021
Rolland M, Gilbert PB.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Progress on Preparation of Desiccants Used in Refrigerant System

Zhileng xuebao, 2006
The desiccants such as silica gel,active alumina,active carbon,and molecular sieve,are employed to purify the contaminations in the refrigerant system.With the development of new refrigerants,the properties of desiccants need to be improved.Based on the ...
王鹏飞, 周永贤, 朱琳, 刘华, 徐静安   +4 more
doaj   +2 more sources

Quantum security analysis of Module-LWE PQC based on practical cost estimates

Transactions on Cryptographic Hardware and Embedded Systems
The security of lattice-based cryptography relies on the computational complexity of solving the Shortest Vector Problem (SVP) on a high-dimensional lattice. Due to its efficacy in addressing SVP, lattice-based cryptographic systems have so far used the
Seong-Min Cho, Changyeol Lee, Seung-Hyun Seo   +2 more
doaj   +1 more source

Resultados numéricos en el problema de la rejilla de Stokes [PDF]

, 1989
En este artículo se presenta un estudio numérico sobre el movimiento de un fluido viscoso incompresible que atraviesa una pared finamente perforada de espesor pequeño (una rejilla).
Conca, Carlos, Sepúlveda, Mauricio
core   +2 more sources