Results 41 to 50 of about 164,349 (320)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

CONVERGENCE OF HEALTH EXPENDITURE IN EU 12 AND V4 STATES

Copernican Journal of Finance & Accounting, 2017
The subject of this paper is an attempt to assess the level of convergence of government health spending in the European Union countries. The ever-increasing level of life expectancy, demographic changes, including the aging of society in many European ...
Piotr Kułyk, Łukasz Augustowski
doaj   +3 more sources

Stochastic sigma-convergence and applications

, 2011
Motivated by the fact that in nature almost all phenomena behave randomly in some scales and deterministically in some other scales, we build up a framework suitable to tackle both deterministic and stochastic homogenization problems simultaneously, and also separately.
Sango, Mamadou, Woukeng, Jean Louis
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Impact of Gross Regional Product Per Capita on the Processes of Convergence between Different Regions of the Country

Qubahan Academic Journal
The purpose of this study was to analyses the dynamics of gross regional product per capita within the regions of Russia from 2005 to 2020, with the objective of examining the presence of convergence among these administrative and territorial units ...
Mayya Dubovik , Sergey Dmitriev , Madina Aitkazina   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Homogenization of a 2D Tidal Dynamics Equation

Mathematics, 2020
This work deals with the homogenization of two dimensions’ tidal equations. We study the asymptotic behavior of the sequence of the solutions using the sigma-convergence method.
Giuseppe Cardone, Aurelien Fouetio, Jean Louis Woukeng   +2 more
doaj   +1 more source

Global Digital Convergence: Impact of Cybersecurity, Business Transparency, Economic Transformation, and AML Efficiency

Journal of Open Innovation: Technology, Market and Complexity, 2022
: The article substantiates the existence of convergence processes in the field of digitization of countries, taking into account the number of Internet users; people with advanced skills; and indicators of infrastructure (network coverage, population ...
Aleksandra Kuzior, Tetiana Vasylieva, Olha Kuzmenko, Vitaliia Koibichuk, Paulina Brożek   +4 more
doaj   +1 more source

Dynamics of the symmetric eigenvalue problem with shift strategies [PDF]

, 2011
A common algorithm for the computation of eigenvalues of real symmetric tridiagonal matrices is the iteration of certain special maps $F_\sigma$ called shifted $QR$ steps. Such maps preserve spectrum and a natural common domain is ${\cal T}_\Lambda$, the
Bloch, Bloch, Carlos Tomei, Deift, Deift, Demmel, Flaschka, Hoffmann, Leite, Leite, Leite, Leite, Moser, Nicolau C. Saldanha, Parlett, Ricardo S. Leite, Sternberg, Symes, Tomei, van Moerbeke, Wilkinson   +20 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source