Results 131 to 140 of about 7,711,295 (297)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Sigma receptor ligands: novel applications in cancer imaging and treatment [PDF]

, 2012
Sigma receptoren (subtypes sigma-1 en sigma-2) zijn unieke bindingsplaatsen die een aanzienlijk hogere expressie vertonen in kanker dan in gezond weefsel.
Rybczynska, Anna A.,, Rybczynska, Anna A.   +1 more
core   +1 more source

Soft theorems for two-scalar sigma models

Journal of High Energy Physics
In this paper, we study the scattering amplitudes and soft theorems for the sigma models with two scalars. We show that if the particles are Goldstone bosons, then you necessarily get Adler zero with no possibility for non-trivial soft theorems.
Karol Kampf, Jiri Novotny, Mikhail Shifman, Jaroslav Trnka   +3 more
doaj   +1 more source

Conformal superspace sigma-models

, 2011
We review recent developments in the context of two-dimensional conformally invariant sigma-models. These quantum field theories play a prominent role in the covariant superstring quantization in flux backgrounds and in the analysis of disordered systems.
Mitev, V., Quella, T., Schomerus, V.
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Infrared properties of two-dimensional SU(N)/H nonlinear $\sigma$ models at nonzero $\theta$ angles

SciPost Physics
A general strategy is proposed to explore the low-energy properties of two-dimensional nonlinear $\sigma$ models with $\theta$ terms. We demonstrate its application to nonlinear $\sigma$ models with the target space $SU(N)/H$, which include $\mathbb{C}P^{
Philippe Lecheminant, Yuya Tanizaki, Keisuke Totsuka
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Sigma Models and Minimal Surfaces

Letters in Mathematical Physics, 1998
The correspondance is established between the sigma models, the minimal surfaces and the Monge-Ampere equation. The Lax -Pairs of the minimality condition of the minimal surfaces and the Monge-Ampere equations are given. Existance of infinitely many nonlocal conservation laws is shown and some Backlund transformations are also given.
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Six Sigma vs. Design for Six Sigma: selection of the requisite Six Sigma approach using multi-criteria decision analysis: innovation report [PDF]

The literature suggests that organisations which have adopted Six Sigma have realised that upon achieving a Five Sigma level the only way to surpass this is to redesign the process(es) by means of Design for Six Sigma (DFSS). For others, the selection of
Bañuelas, Ricardo
core