Results 141 to 150 of about 2,430,073 (342)

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Nicolai maps for supersymmetric sigma models

Journal of High Energy Physics
Supersymmetric field theories can be characterized by their Nicolai map, which is a nonlinear and nonlocal field transformation to their free-field limit.
Olaf Lechtenfeld
doaj   +1 more source

String compactifications on Calabi-Yau stacks

, 2005
In this paper we study string compactifications on Deligne-Mumford stacks. The basic idea is that all such stacks have presentations to which one can associate gauged sigma models, where the group gauged need be neither finite nor effectively-acting ...
Abouelsaood, Abramovich, Adams, Aspinwall, Aspinwall, Beauville, Bridgeland, Caldararu, Callan, Chen, Donagi, Douglas, Douglas, Douglas, Douglas, Edidin, El Kacimi-Alaoui, Eric Sharpe, Freed, Ginsparg, Gomez, Gomez, Harvey, Ito, Katz, Katz, Kresch, Mohri, Pantev, Pantev, Sharpe, Sharpe, Sharpe, Sharpe, Sharpe, Silverstein, Tony Pantev, Totaro, Vistoli, Witten, Witten, Witten   +41 more
core   +3 more sources

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Poisson-Lie sigma models over low dimensional real Poisson-Lie groups [PDF]

arXiv, 2010
The Poisson-Lie sigma models over nonsemisimple low dimensional real Poisson-Lie groups are investigated. We find two sided models on two, three and some four dimensional Poisson-Lie groups where the Poisson-Lie sigma models over Poisson-Lie groups G and its dual $\tilde{G}$ are topological sigma models or BF gauge models.
arxiv  

Duality, Quotients, and Currents

, 1991
We study the generalization of $R\to 1/R$ duality to arbitrary conformally invariant sigma models with an isometry. We show that any pair of dual sigma models can be represented as quotients of a self-dual sigma model obtained by gauging different ...
Bagger, Buscher, Buscher, Buscher, Buscher, Erik Verlinde, Fayet, Fridling, Gates, Gates, Giveon, Hitchin, Hull, Hull, Kikkawa, Kiritsis, Lindström, Martin Roček, Roček, Siegel, Tseytlin, Witten, Zumino   +22 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

A Finite-Element Formulation for the Vertical Discretization of Sigma-Coordinate Primitive Equation Models [PDF]

, 1977
Andrew Staniforth, Roger Daley
openalex   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Spectra of sigma models on semi-symmetric spaces

Nuclear Physics B, 2016
Sigma models on semi-symmetric spaces provide the central building block for string theories on AdS backgrounds. Under certain conditions on the global supersymmetry group they can be made one-loop conformal by adding an appropriate fermionic Wess–Zumino
Alessandra Cagnazzo, Volker Schomerus, Vaclav Tlapak   +2 more
doaj   +1 more source