Results 211 to 220 of about 452,071 (254)

Artificial intelligence-driven integration of multi-biofluid omics and clinical phenotype enables stratification of endometrial cancer. [PDF]

Cell Rep Med
Li D, Wu P, Zheng J, Yang Y, Shan W, Yi J, Zhao D, Yang S, Hu Y, Zhu X, Fan R, Fu P, Bai C, Chen X, Qiao L.   +14 more
europepmc   +1 more source

A family portrait of lanmodulin selectivity for enhanced rare-earth separations. [PDF]

Nat Chem Biol
Diep P, Madsen CS, Choi W, Dong Z, Kang-Yun CS, Uychoco PFV, Seidel JA, Eaton SA, Jiao Y, Cotruvo JA, Park DM.   +10 more
europepmc   +1 more source

Generation of human sequence antibodies in OmniChicken against the highly conserved mammalian target BDNF using three distinct discovery workflows. [PDF]

MAbs
Ching KH, Keating S, Zeng B, Espinosa DA, Stack E, Wall S, Beyer S, Wade J, Tam A, Cunningham O, Chowdhury R, Zhang Y, Morales J, Abdiche Y, Leighton PA, Darmanin Sheehan A, Harriman W.   +16 more
europepmc   +1 more source

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Predicting thermophysical properties of dialkylimidazolium ionic liquids from sigma profiles

Journal of Molecular Liquids, 2021
Abstract We present a Support Vector Regression (SVR) machine learning framework for predicting the viscosity, ionic conductivity, and density of imidazolium ionic liquids (ILs) using a universal set of features extracted from COSMO-RS sigma profiles.
Michael Baldea, Mark Stadtherr, Joan Brennecke   +2 more
exaly   +2 more sources

Six Sigma for improving aesthetic defects in aluminum profiles facility

Facilities, 2017
Purpose This paper aims to develop a quality plan to detect aesthetic defects in extruded aluminum profiles before the fabrication stage based on the Six Sigma improvement methodology in an aluminum facility. These defects are hard to be detected at the fabrication stage. It is also hard to be fixed in the site.
Abdulaziz A Bubshait, Laith Hadidi
exaly   +2 more sources

Exploring the Selectivity Profile of Sigma Receptor Ligands by Molecular Docking and Pharmacophore Analyses

Medicinal Chemistry, 2021
Background: Sigma receptors (Rs), initially classified as an additional class of opioid receptors, are now recognized as a unique entity with no homology to opioid receptors divided into two distinct subtypes, namely σ1R and σ2R. σ1R-targeting ligands have been conceived and explored for the treatment of various neurodegenerative disorders and ...
Righetti G., Tonelli M., Fossa P., Cichero E.   +3 more
openaire   +2 more sources

Novel Sigma Receptor Ligands:  Synthesis and Biological Profile

Journal of Medicinal Chemistry, 2007
The aim of the present study was to investigate the biological profile of new substituted 1-phenyl-2-cyclopropylmethylamines. High affinity for both sigma subtypes was achieved when 4-phenylpiperidin-4-ol (4a-e) and 4-benzylpiperidine moieties were present (5a-e).
PREZZAVENTO, Orazio, CAMPISI, Agatina, RONSISVALLE, SIMONE, LI VOLTI, Giovanni, MARRAZZO, Agostino, BRAMANTI V, CANNAVO G, VANELLA, LUCA, CAGNOTTO A, MENNINI T, IENTILE R, RONSISVALLE, Giuseppe   +11 more
openaire   +4 more sources