Results 41 to 50 of about 31,354 (258)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Least energy sign-changing solutions for nonlinear problems involving fractional Laplacian
Electronic Journal of Differential Equations, 2016 In this article, we study the existence of least energy sign-changing solutions for nonlinear problems involving fractional Laplacian. By introducing some new ideas and combining constraint variational method with the quantitative deformation lemma ...
Zu Gao, Xianhua Tang, Wen Zhang
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Multiple sign-changing solutions for nonlinear fractional Kirchhoff equations
Boundary Value Problems, 2018 This paper is concerned with the following nonlinear fractional Kirchhoff equation: (a+b∫R3|(−Δ)s2u|2dx)(−Δ)su+V(x)u=f(u),x∈R3, $$\biggl(a+b \int _{\mathbb{R}^{3}} \bigl\vert (-\Delta )^{\frac{s}{2}}u \bigr\vert ^{2}\,dx \biggr) (- \Delta )^{s}u+V(x)u=f ...
Yang Wang, Yansheng Liu, Yujun Cui
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Boundary Value Problems, 2010 Our aim is the study of a class of nonlinear elliptic problems under Neumann conditions involving the -Laplacian. We prove the existence of at least three nontrivial solutions, which means that we get two extremal constant-sign solutions and one sign ...
Winkert Patrick
doaj +2 more sources
Sign-changing solutions of p-Laplacian equation with a sub-linear nonlinearity at infinity
Electronic Journal of Differential Equations, 2013 In this article we obtain some existence and multiplicity results for sign-changing solutions of a $p$-Laplacian equation. We use the method of lower and upper solutions and Leray-Schauder degree theory.
Xian Xu, Bin Xu
doaj
On a class of superlinear nonlocal fractional problems without Ambrosetti–Rabinowitz type conditions
Electronic Journal of Qualitative Theory of Differential Equations, 2019 In this note, we deal with the existence of infinitely many solutions for a problem driven by nonlocal integro-differential operators with homogeneous Dirichlet boundary conditions \begin{equation*} \begin{cases} -\mathcal{L}_{K}u=\lambda f(x,u), &
Qing-Mei Zhou
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Solutions of the fractional Schrödinger equation with a sign-changing nonlinearity
Journal of Mathematical Analysis and Applications, 2017 We look for a solutions to a nonlinear, fractional Schrödinger equation $$(-Δ)^{α/ 2}u + V(x)u = f(x,u)-Γ(x)|u|^{q-2}u\hbox{ on }\mathbb{R}^N,$$ where potential $V$ is coercive or $V=V_{per} + V_{loc}$ is a sum of periodic in $x$ potential $V_{per}$ and localized potential $V_{loc}$, $Γ\in L^{\infty}(\mathbb{R}^N)$ is periodic in $x$, $Γ(x)\geq 0$ for ...
openaire +2 more sources