Results 61 to 70 of about 31,354 (258)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Infinitely many sign-changing solutions for a Schrö dinger equation [PDF]

Advances in Difference Equations, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Multiplicity of Positive Solutions for a Singular Tempered Fractional Initial-Boundary Value Problem with Changing-Sign Perturbation Term

Fractal and Fractional
In this paper, we focus on the multiplicity of positive solutions for a singular tempered fractional initial-boundary value problem with a p-Laplacian operator and a changing-sign perturbation term.
Xinguang Zhang, Peng Chen, Lishuang Li, Yonghong Wu   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Sign-changing solutions of variational inequality

In this paper, we are concerned with the sign-changing solutions of variational inequality problems. In order to give the existence results of the sign-changing solutions for variational inequality problems, we first construct a suitable penalty problem related to the variational inequality, and prove the existence of a sign-changing solution for this ...
Xian, Xu, Taotao, Wang
openaire   +2 more sources

Some remarks on the stability of sign changing solutions

Tohoku Mathematical Journal, 1995
This paper deals with the study of the stability properties of the changing sign solutions of the problems: \[ - \Delta u= h(u)\quad\text{in}\quad D,\quad u= 0\quad\text{on}\quad \partial D,\quad\text{or}\quad {\partial u\over \partial n}= 0\quad\text{on}\quad \partial D, \] \[ - \varepsilon^2 \Delta u= h(u)\quad\text{in}\quad D,\quad u= 0\quad\text{on}
Dancer, E. Norman, Guo, Zong Ming
openaire   +3 more sources

A sign-changing solution for nonlinear problems involving the fractional Laplacian

Electronic Journal of Differential Equations, 2015
In this article, we establish the existence of a least energy sign-changing solution for nonlinear problems involving the fractional Laplacian. Our main tool is constrained minimization in a closed subset containing all the sign-changing solutions of ...
Kaimin Teng, Kun Wang, Ruimeng Wang
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source