Results 51 to 60 of about 4,806,032 (244)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Multiple sign-changing solutions for nonlinear fractional Kirchhoff equations
Boundary Value Problems, 2018 This paper is concerned with the following nonlinear fractional Kirchhoff equation: (a+b∫R3|(−Δ)s2u|2dx)(−Δ)su+V(x)u=f(u),x∈R3, $$\biggl(a+b \int _{\mathbb{R}^{3}} \bigl\vert (-\Delta )^{\frac{s}{2}}u \bigr\vert ^{2}\,dx \biggr) (- \Delta )^{s}u+V(x)u=f ...
Yang Wang, Yansheng Liu, Yujun Cui
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Boundary Value Problems, 2010 Our aim is the study of a class of nonlinear elliptic problems under Neumann conditions involving the -Laplacian. We prove the existence of at least three nontrivial solutions, which means that we get two extremal constant-sign solutions and one sign ...
Winkert Patrick
doaj +2 more sources
On a class of superlinear nonlocal fractional problems without Ambrosetti–Rabinowitz type conditions
Electronic Journal of Qualitative Theory of Differential Equations, 2019 In this note, we deal with the existence of infinitely many solutions for a problem driven by nonlocal integro-differential operators with homogeneous Dirichlet boundary conditions \begin{equation*} \begin{cases} -\mathcal{L}_{K}u=\lambda f(x,u), &
Qing-Mei Zhou
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Construction of pseudo-gradient vector field and sign-changing multiple solutions involving p-Laplacian [PDF]
, 2004 Existence of multiple and sign-changing solutions for a problem involving p-Laplacian and jumping nonlinearities are considered via the construction of descent flow in C01(Ω̄). Sign-changing and multiple solutions are obtained under additional assumption
Chen, Jianqing +2 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source