Results 71 to 80 of about 4,806,032 (244)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Blow up and symmetry of sign changing solutions to some critical elliptic equations [PDF]

, 2006
In this paper we continue the analysis of the blow-up of low energy sign-changing solutions of semi-linear elliptic equations with critical Sobolev exponent, started in [M. Ben Ayed, K. El Mehdi, F.
EL MEHDI K, Filomena Pacella, Mohamed Ben Ayed, Khalil El Mehdi, Ben Ayed, Mohamed, El Mehdi, Khalil, BEN AYED M, PACELLA, Filomena   +7 more
core   +1 more source

Sign-changing solutions for a nonlinear degenerate elliptic system [PDF]

In this article, we study the multiplicity of weak solutions to the non-linear degenerate elliptic system. The existence of sign-changing solutions is proved by the truncation method and the invariant sets of descending flow ...
Trong, Duong, Thi Hong Hanh, Le
core   +1 more source

Sign-changing solutions of a fourth-order elliptic equation with supercritical exponent

Electronic Journal of Differential Equations, 2014
In this article we study the nonlinear elliptic problem involving nearly critical exponent $$\displaylines{ \Delta^2 u = |u|^{8/(n-4)+\varepsilon}u\quad\text{in } \Omega, \cr \Delta u=u = 0\quad \text{on } \partial \Omega, }$$ where $\Omega $ is a
Kamal Ould Bouh
doaj  

Multiplicity of Positive Solutions for a Singular Tempered Fractional Initial-Boundary Value Problem with Changing-Sign Perturbation Term

Fractal and Fractional
In this paper, we focus on the multiplicity of positive solutions for a singular tempered fractional initial-boundary value problem with a p-Laplacian operator and a changing-sign perturbation term.
Xinguang Zhang, Peng Chen, Lishuang Li, Yonghong Wu   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Constant-sign and nodal solutions for a Neumann problem with p-laplacian and equi-diffusive reaction term

, 2011
The existence of both constant and sign-changing (namely, nodal) solutions to a Neumann boundary-value problem with $p$-Laplacian and reaction term depending on a positive parameter is established. Proofs make use of sub- and super-solution techniques as
Marano, Salvatore A., Papageorgiou, NS, Papageorgiou, Nikolaos S., Marano, SA   +3 more
core  

Sign-Changing Solutions for Nonlinear Elliptic Problems Depending on Parameters

, 2010
The study of multiple solutions for quasilinear elliptic problems under Dirichlet or nonlinear Neumann type boundary conditions has received much attention over the last decades.
Siegfried Carl, Dumitru Motreanu
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Resultados de existência para equações elípticas com termos singulares [PDF]

, 2013
Doutoramento em Matemática e AplicaçõesEsta dissertação estuda em detalhe três problemas elípticos: (I) uma classe de equações que envolve o operador Laplaciano, um termo singular e nãolinearidade com o exponente crítico de Sobolev, (II) uma classe de ...
Murillo, Kelly Patricia
core