Results 81 to 90 of about 31,354 (258)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Sign changing solutions of nonlinear elliptic equations
Advances in Differential Equations, 1996 The paper is concerned with the nonlinear elliptic problem \[ \text{div} (a_\varepsilon(x)Du)+ g(x,u)=0, \quad u^+\not\equiv 0,\;u^-\not\equiv 0\quad\text{ in }\Omega\qquad\text{and}\quad u=0\text{ on }\partial\Omega, \leqno (P_\varepsilon) \] where \(\Omega\) is a bounded domain in \(\mathbb{R}^N\) with \(N\geq 1\), \(a_\varepsilon(x)= (a_\varepsilon^{
M. Musso, PASSASEO, Donato
openaire +4 more sources
Electronic Journal of Differential Equations, 2012 In this article, we study the second-order three-point boundary-value problem $$displaylines{ u''(t)+a(t)u'(t)+f(t,u)=0,quad 0 leq t leq 1, cr u'(0)=0,quad u(1)=alpha u(eta), }$$ where $0<alpha$, $eta<1$, $ain C([0,1],(-infty, 0))$ and $f$ is
Jian Liu, Zengqin Zhao
doaj
Global structure of sign-changing solutions for discrete Dirichlet problems
Open Mathematics, 2020 Let T>1T\gt 1 be an integer, T≔[1,T]Z={1,2,…,T},Tˆ≔{0,1,…,T+1}{\mathbb{T}}:= {{[}1,T]}_{{\mathbb{Z}}}=\{1,2,\ldots ,T\},\hspace{.0em}\hat{{\mathbb{T}}}:= \{0,1,\ldots ,T+1\}.
Wei Liping, Ma Ruyun
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On sign-changing solutions for nonlinear operator equations
Journal of Mathematical Analysis and Applications, 2007 In the paper, the existence of sign-changing solutions for nonlinear operator equations in ordered Banach spaces is discussed by using the topological degree and fixed point index theory. The authors obtain some new three-solution theorems for fixed point equations of increasing operators and for general operators.
Li, Fuyi +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source