Results 81 to 90 of about 4,806,032 (244)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Multiple sign-changing solutions for Kirchhoff type problems

Electronic Journal of Differential Equations, 2016
This article concerns the existence of sign-changing solutions to nonlocal Kirchhoff type problems of the form $$ -\Big(a+b\int_\Omega|\nabla u|^2dx\Big)\Delta u=f(x,u) \text{ in }\Omega,\quad u=0 \text{ on }\partial\Omega, $$ where $\Omega$ is a ...
Cyril Joel Batkam
doaj  

Nonradial solutions for semilinear Schrödinger equations with sign-changing potential

Electronic Journal of Qualitative Theory of Differential Equations, 2015
In this paper, we investigate the existence of infinite nonradial solutions for the Schrödinger equations \begin{equation*} \begin{cases} -\triangle u+b(|x|)u=f(|x|, u), &\quad x\in {\mathbb{R}}^{N},\\ u\in H^{1}({\mathbb{R}}^{N}), \end ...
Dingyang Lv, Xuxin Yang
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Ground-state sign-changing homoclinic solutions for a discrete nonlinear p-Laplacian equation with logarithmic nonlinearity

Boundary Value Problems
By using a direct non-Nehari manifold method from (Tang and Cheng in J. Differ. Equ. 261:2384–2402, 2016), we obtain an existence result of ground-state sign-changing homoclinic solutions that only changes sign once and ground-state homoclinic solutions ...
Xin Ou, Xingyong Zhang
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Clustered boundary layer sign-changing solutions for a supercritical problem

, 2013
We study the existence and profile of sign-changing solutions of the supercritical problem -Delta u = |u|(p-1)u in D, u = 0 on partial derivative D, where D is a smooth open bounded domain in R-n and p > 1. In particular, for suitable domains D, we prove
S. Kim, PISTOIA, Angela
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Multiple positive solutions for second-order three-point boundary-value problems with sign changing nonlinearities

Electronic Journal of Differential Equations, 2012
In this article, we study the second-order three-point boundary-value problem $$displaylines{ u''(t)+a(t)u'(t)+f(t,u)=0,quad 0 leq t leq 1, cr u'(0)=0,quad u(1)=alpha u(eta), }$$ where $0<alpha$, $eta<1$, $ain C([0,1],(-infty, 0))$ and $f$ is
Jian Liu, Zengqin Zhao
doaj  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source