Results 61 to 70 of about 4,685,588 (297)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Unsupervised spatially embedded deep representation of spatial transcriptomics
Genome MedicineOptimal integration of transcriptomics data and associated spatial information is essential towards fully exploiting spatial transcriptomics to dissect tissue heterogeneity and map out inter-cellular communications.
Hang Xu +13 more
doaj +1 more source
Magnitude and Sign Correlations in Heartbeat Fluctuations
, 2001 We propose an approach for analyzing signals with long-range correlations by decomposing the signal increment series into magnitude and sign series and analyzing their scaling properties.
A. Babloyantz +20 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Production and Comprehension of Prosodic Markers in Sign Language Imperatives
Frontiers in Psychology, 2018 In signed and spoken language sentences, imperative mood and the corresponding speech acts such as for instance, command, permission or advice, can be distinguished by morphosyntactic structures, but also solely by prosodic cues, which are the focus of ...
Diane Brentari +5 more
doaj +1 more source
, 2018 The method of 1-bit ("sign-sign") random projections has been a popular tool for efficient search and machine learning on large datasets. Given two $D$-dim data vectors $u$, $v\in\mathbb{R}^D$, one can generate $x = \sum_{i=1}^D u_i r_i$, and $y = \sum_ ...
Li, Ping
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Nature Communications, 2017 Immune checkpoint blockade (ICB) therapies can unleash anti-tumour T-cell responses. Here the authors show, by integrating MHC tetramer multiplexing, mass cytometry and high-dimensional analyses, that neoantigen-specific, tumour-infiltrating T cells are ...
M. Fehlings +9 more
doaj +1 more source
Nature Communications, 2023 Advances in spatial transcriptomics technologies have enabled the gene expression profiling of tissues while retaining spatial context. Here the authors present GraphST, a graph self-supervised contrastive learning method that learns informative and ...
Yahui Long +15 more
doaj +1 more source
Scalable ASL sign recognition using model-based machine learning and linguistically annotated corpora [PDF]
, 2018 We report on the high success rates of our new, scalable, computational approach for sign recognition from monocular video, exploiting linguistically annotated ASL datasets with multiple signers.
Dilsizian, Mark +2 more
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