Results 71 to 80 of about 6,175,859 (338)

Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway

Frontiers in Immunology, 2018
Calcineurin (Cn) is a protein phosphatase that regulates the activation of the nuclear factor of activated T-cells (NFAT) family of transcription factors, which are key regulators of T-cell development and function.
Andrea Mencarelli, Maurizio Vacca, Maurizio Vacca, Hanif Javanmard Khameneh, Enzo Acerbi, Alicia Tay, Francesca Zolezzi, Michael Poidinger, Alessandra Mortellaro, Alessandra Mortellaro   +9 more
doaj   +1 more source

Nuclear Lattice Simulations using Symmetry-Sign Extrapolation [PDF]

, 2015
Projection Monte Carlo calculations of lattice Chiral Effective Field Theory suffer from sign oscillations to a varying degree dependent on the number of protons and neutrons.
Epelbaum, Evgeny, Krebs, Hermann, Lee, Dean, Luu, Thomas, Lähde, Timo A., Meißner, Ulf-G., Rupak, Gautam   +6 more
core   +2 more sources

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

Scalable ASL sign recognition using model-based machine learning and linguistically annotated corpora [PDF]

, 2018
We report on the high success rates of our new, scalable, computational approach for sign recognition from monocular video, exploiting linguistically annotated ASL datasets with multiple signers.
Dilsizian, Mark, Metaxas, Dimitris, Neidle, Carol   +2 more
core  

Computational complexity and fundamental limitations to fermionic quantum Monte Carlo simulations

, 2004
Quantum Monte Carlo simulations, while being efficient for bosons, suffer from the "negative sign problem'' when applied to fermions - causing an exponential increase of the computing time with the number of particles.
E. Farhi, Matthias Troyer, S. Cook, Uwe-Jens Wiese   +3 more
core   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser, Claire Laurie, Teresa Schmidt, Irene von Luettichau, Peter Bekkering, Sabine Kesting   +5 more
wiley   +1 more source

Mapping the Diversity of Follicular Helper T Cells in Human Blood and Tonsils Using High-Dimensional Mass Cytometry Analysis

Cell Reports, 2015
Single-cell analysis technologies such as mass cytometry allow for measurements of cellular heterogeneity with unprecedented dimensionality. Here, we applied dimensionality reduction and automated clustering methods on human T helper (TH) cells derived ...
Michael T. Wong, Jinmiao Chen, Sriram Narayanan, Wenyu Lin, Rosslyn Anicete, Henry Tan Kun Kiaang, Maria Alicia Curotto De Lafaille, Michael Poidinger, Evan W. Newell   +8 more
doaj   +1 more source

Mitochondrial Dysfunction in CD4+ T Effector Memory RA+ Cells

Biology, 2023
Human ageing is accompanied by poor responses to infection and decreased vaccine efficacy. While the causes of this can be attributed to defects in the immune system that increase with age, it is unknown whether mitochondrial dysfunction may also ...
Marie Strickland, Salanne Lee, Shi Yong Neo, Akhila Balachander, Ivy Low, Seri Mustafah, Wah Ing Goh, Graham D. Wright, Anis Larbi, Sylvia L. F. Pender   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source