Results 61 to 70 of about 1,192,373 (315)
Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits
Nature Communications, 2020 Metformin is an anti-diabetic drug that has shown promise to reduce M. tuberculosis susceptibility. Here the authors show that this effect is a result of metformin-mediated activation of anti-mycobacterial memory-like antigen-inexperienced CD8+CXCR3+ T ...
Julia Böhme +20 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
LinguisticsCorpus methods are now established within the field of signed language linguistics. Empirical investigations of signed language corpora have challenged many early assumptions about the nature of deaf community signed languages, while making us more aware
Puupponen Anna +7 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Sign Tests for Long-memory Time Series [PDF]
, 2005 This paper proposes sign-based tests for simple and composite hypotheses on the long-memory parameter of a time series process. The tests allow for nonstationary hypothesis, such as unit root, as well as for stationary hypotheses, such as weak dependence
Delgado, Miguel A., Velasco, Carlos
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
, 2020 Every few months the same debate pops up in the open science circles in my Twitter feed, and we go round and round about whether people in general should sign their manuscript reviews. (The last time I saw it, it was an interesting <strong> Everything Hertz </strong> episode.
openaire +1 more source
Guideline sign code, a format for the municipal regulation of on-premise signs
, 1981 Special funding to assist in the production and distribution of this publication was provided by the World Sign ...
National Electric Sign Association
core
An example-based approach to translating sign language [PDF]
, 2005 Users of sign languages are often forced to use a language in which they have reduced competence simply because documentation in their preferred format is not available.
Morrissey, Sara +3 more
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source