Results 61 to 70 of about 7,799 (146)
Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection.
PLoS ONE, 2012 The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated by the CCL2/CCR2 axis are critical steps in determining the host immune response to fungi.
Juan Sainz +8 more
doaj +1 more source
Universality classes of interaction structures for NK fitness landscapes
, 2018 Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic fitness landscapes that aim to capture generic features of epistatic interactions in multilocus systems. Genotypes are represented as sequences of $L$ binary loci.
Ferretti, Luca +3 more
core +2 more sources
GenePath: a System for Automated Construction of Genetic Networks from Mutant Data [PDF]
, 2003 Motivation: Genetic pathways are often used in the analysis of biological phenomena. In classical genetics, they are constructed manually from experimental data on mutants. The field lacks formalism to guide such analysis, and accounting for all the data
Bratko, Ivan +6 more
core +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Genomic selection (GS) is critical for accelerating genetic gain in modern plant breeding. Deep learning approaches offer powerful non‐linear representation capabilities for modelling non‐additive effects. However, their application in GS remains restricted, as high‐dimensional, low‐sample and noisy data hinder the identification of ...
Yuexin Ma +7 more
wiley +1 more source
Epistasis and Shapes of Fitness Landscapes [PDF]
, 2006 The relationship between the shape of a fitness landscape and the underlying gene interactions, or epistasis, has been extensively studied in the two-locus case. Gene interactions among multiple loci are usually reduced to two-way interactions.
Beerenwinkel, Niko +2 more
core +4 more sources
Modelling epistasis in genetic disease using Petri nets, evolutionary computation and frequent itemset mining [PDF]
, 2010 Petri nets are useful for mathematically modelling disease-causing genetic epistasis. A Petri net model of an interaction has the potential to lead to biological insight into the cause of a genetic disease.
Beretta, Lorenzo, Mayo, Michael
core +2 more sources
Plant, Cell &Environment, EarlyView.ABSTRACT Rising nighttime temperature (Tnight) can reduce crop yields while low Tnight may restrict plant growth and development. Despite quantifiable effects of Tnight, genetic basis underlying plant responses to Tnight remains unclear. We investigated natural variation in long‐term response of effective photosynthetic efficiency (Fq’/Fm’) to Tnight ...
Ana Carolina dos Santos Sá +5 more
wiley +1 more source
Sign Epistasis and the Geometry of Interactions
, 2018 Approaches to gene interactions based on sign epistasis have been highly influential in recent time. Sign epistasis is useful for relating local and global properties of fitness landscapes, as well as for analyzing evolutionary trajectories and constraints.
openaire +2 more sources
Elasticity sampling links thermodynamics to metabolic control [PDF]
, 2013 Metabolic networks can be turned into kinetic models in a predefined steady state by sampling the reaction elasticities in this state. Elasticities for many reversible rate laws can be computed from the reaction Gibbs free energies, which are determined ...
Liebermeister, Wolfram
core +2 more sources
Combining phenomic and genomic selection for pea breeding improvement
The Plant Phenome Journal, Volume 9, Issue 1, December 2026.Abstract Pea (Pisum sativum L.) is a strategic crop in the development of sustainable agriculture. However, the genetic gain remains limited despite advances in breeding. Genomic selection holds promise to accelerate varietal improvement, but its high implementation cost restricts its use in crops.
Anthony Klein +15 more
wiley +1 more source