Results 81 to 90 of about 7,799 (146)

When South Meets North: A Joint Contact Zone Coinciding With Environmental Gradients in Three Boreal Tree Species

Molecular Ecology, Volume 35, Issue 8, April 2026.
ABSTRACT Post‐glacial recolonisation of Fennoscandia created secondary contact zones in many species, offering opportunities to study how gene flow and selection contribute to their establishment and maintenance. Here, we analyse genomic data from three boreal tree species—Picea abies, Betula pendula and Pinus sylvestris—sampled along a latitudinal ...
Pilar Herrera‐Egoavil, J. Luis Leal, Qiujie Zhou, Pascal Milesi, Martin Lascoux, Burçin Yıldırım   +5 more
wiley   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Genomic Adaptations to the Loss of a Conserved Bacterial DNA Methyltransferase

mBio, 2015
CcrM is an orphan DNA methyltransferase nearly universally conserved in a vast group of Alphaproteobacteria. In Caulobacter crescentus, it controls the expression of key genes involved in the regulation of the cell cycle and cell division.
Diego Gonzalez, Justine Collier
doaj   +1 more source

Evolution of Senescence by Damage Accumulation That Accelerates With Age Throughout an Organism's Lifespan

Ecology and Evolution, Volume 16, Issue 3, March 2026.
Senescence evolution is usually explained by reduced selection on late acting genes. Here we develop a new model for senescence evolution that complements the classic theory by focusing on genes that affect mortality throughout lifespan. Our work sheds light on the dynamics of senescence evolution and helps to reconcile phenomena that presented ...
Darar Bega, Lilach Hadany
wiley   +1 more source

Inheritance of a sign of apricot color of ray flowers of sunflower (Helianthus annuus L.)

Plant Varieties Studying and Protection, 2019
Purpose. To reveal the nature of the inheritance of apricot color of the ray flowers of the sunflower and the type of interaction of genes causing different colors. Methods. Field experiment, genetic analysis. The statistical validity of the results was
К. В. Ведмедєва
doaj   +1 more source

Genomic selection of root‐knot nematode (Meloidogyne enterolobii) resistance in watermelon wild relatives (Citrullus amarus)

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Meloidogyne enterolobii is a virulent root‐knot nematode (RKN) species posing a significant threat to watermelon production across the United States. The USDA, ARS, Plant Introduction (PI) collection of Citrullus amarus, a wild relative of cultivated watermelon (Citrullus lanatus), contains RKN‐resistance. However, incorporating RKN resistance
Anju Biswas, Homan Regmi, Benjamin D. Waldo, Sandra Branham, Pat Wechter, Shaker Kousik, Diego Jarquin, Amnon Levi, William B. Rutter   +8 more
wiley   +1 more source

Sign epistasis extends the effects of balancing selection on genetic diversity

AbstractBalancing selection, a form of selection that maintains genetic diversity, is difficult to detect, and the importance of balancing selection for the maintenance of genetic variation may be larger than often assumed. We use modeling to explore the possibility that the diversity-promoting effects of balancing selection extend to other loci that ...
Ksenia A. Khudiakova, Nicholas H. Barton, Goran Arnqvist   +2 more
openaire   +1 more source

Optimizing enzyme thermostability by combining multiple mutations using protein language model

mLife
Optimizing enzyme thermostability is essential for advancements in protein science and industrial applications. Currently, (semi‐)rational design and random mutagenesis methods can accurately identify single‐point mutations that enhance enzyme ...
Jiahao Bian, Pan Tan, Ting Nie, Liang Hong, Guang‐Yu Yang   +4 more
doaj   +1 more source

Contributions of renin-angiotensin system-related gene interactions to obesity in a Chinese population.

PLoS ONE, 2012
BackgroundGene-gene interactions may be partly responsible for complex traits such as obesity. Increasing evidence suggests that the renin-angiotensin system (RAS) contributes to the etiology of obesity.
Jian-Bo Zhou, Chang Liu, Wen-Yan Niu, Zhong Xin, Mei Yu, Jian-Ping Feng, Jin-Kui Yang   +6 more
doaj   +1 more source

Evolutionary accessibility of modular fitness landscapes

, 2013
A fitness landscape is a mapping from the space of genetic sequences, which is modeled here as a binary hypercube of dimension $L$, to the real numbers. We consider random models of fitness landscapes, where fitness values are assigned according to some ...
Krug, Joachim, Schmiegelt, Benjamin
core   +1 more source