Results 81 to 90 of about 35,633 (306)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Valuing All Languages in Europe [PDF]

, 2007
The VALEUR project (2004-2007) took as its focus the 'additional' languages of Europe. These are defined as all languages in use in contexts where they are not 'national', 'official', or 'dominant' languages.
McPake, Joanna, Mijares, Laura, , European Centre for Modern Languages, Council of Europe (Graz, A, European Centre for Modern Languages, Council of Europe (Graz, Austria), European Centre for Modern Languages, Council of Europe (Graz, Austria) (Funder), Latomaa, Sirkku, Martyniuk, Waldemar, Tinsley, Teresa, Broeder, Peter   +8 more
core  

Argument Structure of Classifier Predicates: Canonical and Non-canonical Mappings in Four Sign Languages

Open Linguistics, 2019
We analyze argument structure of whole-entity and handling classifier predicates in four sign languages (Russian Sign Language, Sign Language of the Netherlands, German Sign Language, and Kata Kolok) using parallel datasets (retellings of the Canary Row ...
Kimmelman Vadim, de Lint Vanja, de Vos Connie, Oomen Marloes, Pfau Roland, Vink Lianne, Aboh Enoch O.   +6 more
doaj   +1 more source

Differential object marking in sign languages

Glossa, 2019
Sign languages are sometimes claimed to lack argument marking, yet they exhibit many devices to track and disambiguate referents. In this paper, I will argue that there are devices found across sign languages that demonstrate how object marking is a ...
Carl Börstell
doaj   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Assistive translation technology for deaf people: translating into and animating Irish sign language [PDF]

, 2008
Machine Translation (MT) for sign languages (SLs) can facilitate communication between Deaf and hearing people by translating information into the native and preferred language of the individuals.
Morrissey, Sara
core  

Emerging Sign Languages of the Americas/ Olivier Le Guen, Josefina Safar, Marie Coppola. [PDF]

, 2020
In English.This volume is the first to bring together researchers studying a range of different types of emerging sign languages in the Americas, and their relationship to the gestures produced in the surrounding communities of hearing individuals ...
Rita Kinil Canché, Safar Josefina, Ben Braithwaite, Le Guen Olivier, Ivani Fusellier, Emmanuella Martinod, Kristian Ali, Brigitte Garcia, Marie Coppola, Laura Horton, Olivier Le Guen, Rodrigo Petatillo Chan, John B. Haviland, Josefina Safar, Coppola Marie, Rebeca Petatillo, John Haviland   +16 more
core  

Sign Languages in Papua New Guinea and the Solomon Islands [PDF]

, 2020
Papua New Guinea (PNG) occupies less than 0.4% of the world's land mass and is home to approximately 0.1% of its population, yet it is host to around 12% of the world's languages.1 Despite its phenomenal diversity of spoken languages and the by-now large
Alan, Rumsey, Reed, Lauren
core   +1 more source

Concrete poetry for the sign language classroom

Calidoscópio, 2020
Concrete poetry creates meaning by relying primarily on visual iconicity likewise sign languages (SLs). As they are visual-gestural languages, their modality allows a more transparent relation between the form of the sign and its meaning.
Maria Mertzani
doaj   +1 more source