Results 211 to 220 of about 609,734 (299)

An Engineered Probiotic Consortium Based on Quorum‐Sensing for Colorectal Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
This work develops an engineered probiotic consortium sensing pH, hypoxia, and lactate in the tumor microenvironment. It releases a lactate‐depleting enzyme (LdhA) and a PD‐L1 nanobody. In humanized mouse models (MC38 and HT‐29 tumors), it achieves durable oscillations, suppresses tumors, activates CD8+, CD4+, IFN‐γ+ T cells, and reduces Foxp3 ...
Yufei Guo   +11 more
wiley   +1 more source

MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang   +18 more
wiley   +1 more source

Multispectral Chiral Quasi‐Bound States in the Continuum Enabled Microfluidics for High‐Throughput Molecular Screening and Quantification

open access: yesAdvanced Science, EarlyView.
A microfluidics‐integrated chiral quasi‐BIC metachip is developed that generates strong broadband CD from 0.5–2.0 THz in aqueous environments. A UMAP algorithm processes the resulting multidimensional CD features for simultaneous biomolecular conformation identification and concentration quantification (0.05–0.3 mg dL−1).
Xinyue Liang   +8 more
wiley   +1 more source

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