Results 131 to 140 of about 2,911,926 (286)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Power Grid Frame Structure Business Data Pointer Signal Synchronization Transmission Scheme
Guangtongxin yanjiuObjectiveThis paper deals with the challenge of rising transmission loads and latency sensitivity in the new power grid, necessitating faster communication network speeds.MethodsA low-latency Synchronous Digital Hierarchy (SDH) frame transmission scheme ...
LIU Jun +7 more
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Extreme signal filtering using amplitude modulation
Известия высших учебных заведений. Поволжский регион:Технические наукиBackground. It is proposed to use amplitude modulation in the tasks of determining the parameters of complex-shaped signals based on decomposition.
N.V. Myasnikova +4 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Modulation recognition driven by signal enhancement
Dianxin kexueThe existing modulation recognition algorithms based on deep learning theory require a large number of IQ signal samples during the training phase. It is difficult to obtain a large number of samples in complex electromagnetic environments, resulting in ...
CHENG Fengyun, ZHOU Jin
doaj +2 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Optimum Mode-Switching-Assisted Constant-Power Single- and Multicarrier Adaptive Modulation
, 2003 A set of optimum mode-switching levels is derived for a generic constant-power adaptive-modulation scheme based on a closed-form expression of the average bit error ratio (BER) and the average bits-per-symbol (BPS) throughput of the adaptive-modulation ...
Choi, B.J., Hanzo, L.
core +1 more source