Results 81 to 90 of about 3,392,560 (298)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Signal Peptide Hydrophobicity Modulates Interaction with the Twin-Arginine Translocase

mBio, 2017
The general secretory pathway (Sec) and twin-arginine translocase (Tat) operate in parallel to export proteins across the cytoplasmic membrane of prokaryotes and the thylakoid membrane of plant chloroplasts.
Qi Huang, Tracy Palmer
doaj   +1 more source

Apolipoprotein M associates to lipoproteins through its retained signal peptide. [PDF]

, 2008
Apolipoprotein M (apoM) is predominantly associated with HDL. In this study, it was investigated whether apoM’s uncleaved signal peptide is necessary for the protein’s ability to associate with lipoproteins.
Dahlbäck, Björn, Axler, Olof, Ahnström, Josefin, Ahnström, Josefin,, Dahlbäck, Björn,, Axler, Olof,, Lund University.   +6 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Optimization of a bacillus sp signal peptide for improved recombinant protein secretion and cell viability in escherichia coli is there an optimal signal peptide design?

, 2012
Recombinant protein fused to an N-terminal signal peptide can be translocated to the periplasm and, eventually, to the extracellular medium of Escherichia coli under specific conditions.
Jonet, M. A., Illias, R. M., Low, K. O., Ismail, N. F.   +3 more
core   +1 more source

Expression of the Bacillus subtilis TasA signal peptide leads to cell death in Escherichia coli due to inefficient cleavage by LepB

, 2021
Bacillus subtilis has five type I signal peptidases, one of these, SipW, is an archaeal-like peptidase. SipW is expressed in an operon (tapA-sipW-tasA) and is responsible for removing the signal peptide from two proteins: TapA and TasA.
Zalucki, YM, Musik, JE, Day, CJ, Jennings, MP, Christopher J. Day, Michael P. Jennings, Joanna E. Musik, Yaramah M. Zalucki   +7 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Peptide-cotton textiles with manifold antibacterial properties

, 2022
The development of antimicrobial materials recently have gained increased interest, especially for the development of medical devices as a practical way to prevent bacterial infections.
Marco Scocchi, Barbara Biondi, Cristina Peggion, Mario Mardirossian   +3 more
core