Results 111 to 120 of about 1,112,644 (355)

Deep proteome and transcriptome mapping of a human cancer cell line

Molecular Systems Biology, 2011
While the number and identity of proteins expressed in a single human cell type is currently unknown, this fundamental question can be addressed by advanced mass spectrometry (MS)‐based proteomics.
Nagarjuna Nagaraj, Jacek R Wisniewski, Tamar Geiger, Juergen Cox, Martin Kircher, Janet Kelso, Svante Pääbo, Matthias Mann   +7 more
doaj   +1 more source

Distinct functions of AKT isoforms in breast cancer: a comprehensive review

Cell Communication and Signaling, 2019
Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT signaling pathway. Moreover, AKT regulates the hallmarks of cancer, e.g. tumor growth, survival and invasiveness of tumor cells. After AKT was discovered in the early 1990s,
Nico Hinz, Manfred Jücker
doaj   +1 more source

Microtubules and signal transduction

Current Opinion in Cell Biology, 1999
Although molecular components of signal transduction pathways are rapidly being identified, how elements of these pathways are positioned spatially and how signals traverse the intracellular environment from the cell surface to the nucleus or to other cytoplasmic targets are not well understood.
Gregg G. Gundersen, Tiffani A. Cook
openaire   +3 more sources

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Kinase Mobility Shift Assay (KiMSA) for Assessing Protein Kinase A Activity

Bio-Protocol
The cAMP-dependent protein kinase (PKA) is one of the most extensively distributed kinases among intracellular signal cascades, with a pivotal role in the regulation of various processes, including the capacitation of sperm cells. Traditional assessments
Analia Novero, Tomás Steeman, Catalina Curcio, Lara Buccolini, Andres Binolfi, Diego Krapf, Mariano Buffone, Dario Krapf, Cintia Stival   +8 more
doaj   +1 more source

The synergistic effect of serotonin and epinephrine on the human platelet at the level of signal transduction [PDF]

, 1987
Didier de Chaffoy de Courcelles, Peter Roevens, Herman Van Belle, Fred De Clerck   +3 more
openalex   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Astabiotics: Antimicrobial Signal Transduction Activators [PDF]

, 2013
poster abstractThe increasing prevalence of multi-drug resistant Gram-negative bacteria is a major public health concern. All available antibiotics are inhibitors of targets essential for virulence or growth.
Chen, L., Fortney, K. R., Krieger, A., Mobley, H. L. T., Pollok, Karen E., Smith, S. N., Spinola, S. M., Wolfe, A. J., Zhang, Z.-Y., Zhou, D.   +9 more
core  

Identification of a signal transduction response sequence element necessary for induction of a Dictyostelium discoideum gene by extracellular cyclic AMP. [PDF]

, 1989
Jovan Pavlovic, Bodduluri Haribabu, Robert P. Dottin   +2 more
openalex   +1 more source