Results 111 to 120 of about 1,119,972 (297)

Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model

Communications Biology
Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even ...
Yuichi Matsui, Fumitaka Muramatsu, Hajime Nakamura, Yoshimi Noda, Kinnosuke Matsumoto, Haruhiko Kishima, Nobuyuki Takakura   +6 more
doaj   +1 more source

Deep proteome and transcriptome mapping of a human cancer cell line

Molecular Systems Biology, 2011
While the number and identity of proteins expressed in a single human cell type is currently unknown, this fundamental question can be addressed by advanced mass spectrometry (MS)‐based proteomics.
Nagarjuna Nagaraj, Jacek R Wisniewski, Tamar Geiger, Juergen Cox, Martin Kircher, Janet Kelso, Svante Pääbo, Matthias Mann   +7 more
doaj   +1 more source

Distinct functions of AKT isoforms in breast cancer: a comprehensive review

Cell Communication and Signaling, 2019
Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT signaling pathway. Moreover, AKT regulates the hallmarks of cancer, e.g. tumor growth, survival and invasiveness of tumor cells. After AKT was discovered in the early 1990s,
Nico Hinz, Manfred Jücker
doaj   +1 more source

Astabiotics: Antimicrobial Signal Transduction Activators [PDF]

, 2013
poster abstractThe increasing prevalence of multi-drug resistant Gram-negative bacteria is a major public health concern. All available antibiotics are inhibitors of targets essential for virulence or growth.
Chen, L., Fortney, K. R., Krieger, A., Mobley, H. L. T., Pollok, Karen E., Smith, S. N., Spinola, S. M., Wolfe, A. J., Zhang, Z.-Y., Zhou, D.   +9 more
core  

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Kinase Mobility Shift Assay (KiMSA) for Assessing Protein Kinase A Activity

Bio-Protocol
The cAMP-dependent protein kinase (PKA) is one of the most extensively distributed kinases among intracellular signal cascades, with a pivotal role in the regulation of various processes, including the capacitation of sperm cells. Traditional assessments
Analia Novero, Tomás Steeman, Catalina Curcio, Lara Buccolini, Andres Binolfi, Diego Krapf, Mariano Buffone, Dario Krapf, Cintia Stival   +8 more
doaj   +1 more source

Signal transduction pathways in the clinical approach: where are we going? [PDF]

, 2016
invited ...
LO VASCO, VINCENZA RITA
core   +1 more source

Full coherent frequency conversion between two microwave propagating modes

, 2012
We demonstrate full frequency conversion in the microwave domain using a Josephson three-wave mixing device pumped at the difference between the frequencies of its fundamental eigenmodes.
Abdo, Baleegh, Bergeal, Nicolas, Devoret, Michel H., Frunzio, Luigi, Hatridge, Michael, Schackert, Flavius, Sliwa, Katrina, Stone, A. Douglas   +7 more
core   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Modeling Evolution of Crosstalk in Noisy Signal Transduction Networks

, 2017
Signal transduction networks can form highly interconnected systems within cells due to network crosstalk, the sharing of input signals between multiple downstream responses.
Mukhopadhyay, Ranjan, Tareen, Ammar, Wingreen, Ned S.   +2 more
core   +1 more source