FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease
Molecular Systems BiologyChronic liver diseases are worldwide on the rise. Due to the rapidly increasing incidence, in particular in Western countries, metabolic dysfunction-associated steatotic liver disease (MASLD) is gaining importance as the disease can develop into ...
Sebastian Burbano de Lara +20 more
doaj +1 more source
FEBS Open Bio, EarlyView.ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren +8 more
wiley +1 more source
The synergistic effect of serotonin and epinephrine on the human platelet at the level of signal transduction [PDF]
, 1987 Didier de Chaffoy de Courcelles +3 more
openalex +1 more source
Identification of a signal transduction response sequence element necessary for induction of a Dictyostelium discoideum gene by extracellular cyclic AMP. [PDF]
, 1989 Jovan Pavlovic +2 more
openalex +1 more source
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
S-adenosylmethionine may not be essential for signal transduction during bacterial chemotaxis [PDF]
, 1987 Alain Borczuk +2 more
openalex +1 more source
Signal transduction in human neutrophil leucocytes: Effects of external Na+ and Ca2+ on cell polarity [PDF]
, 1986 Wendy S. Haston, James Shields
openalex +1 more source
Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis
Advanced Biology, EarlyView.Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard +7 more
wiley +1 more source
Transmembrane Signal Transduction and ACTH‐induced Excessive Grooming in the Rat [PDF]
, 1988 Willem Hendrik Gispen
openalex +1 more source