Results 71 to 80 of about 4,996,865 (347)

Non-equilibrium phase transitions in biomolecular signal transduction

, 2011
We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite of the fact that the phosphorylation-state transitions of
A. J. Ninfa, D. Kültz, David Krakauer, Eric Smith, H. Goldstein, J. Gluckheimer, J. von Neumann, L. V. Keldysh, S. Coleman, S. Gaudet, S. Weinberg, Supriya Krishnamurthy, W. Bialek, Walter Fontana   +13 more
core   +1 more source

Increased entropy of signal transduction in the cancer metastasis phenotype [PDF]

, 2010
Studies into the statistical properties of biological networks have led to important biological insights, such as the presence of hubs and hierarchical modularity. There is also a growing interest in studying the statistical properties of networks in the
A Barrat, A Naderi, A Ozgür, A Platzer, AA Samani, AE Teschendorff, AE Teschendorff, AE Teschendorff, AL Barabasi, Andrew E Teschendorff, B Derrida, C Sotiriou, D Pardoll, D Yee, DM Bates, DP Tuck, F Rapaport, H Jeong, H Yu, HY Chuang, I Ulitsky, IW Taylor, J Schäfer, JD Han, JD Storey, JJ Hornberg, K Chin, KR Brown, M Barthelemy, M Neuberg, M Schmidt, MA Pujana, P Farmer, PF Jonsson, RK Nibbe, S Loi, S Negrini, SF Chin, Simone Severini, SL Carter, TS Prasad, U Stelzl, Y Wang   +42 more
core   +5 more sources

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Firing and signal transduction associated with an intrinsic oscillation in neuronal systems [PDF]

, 1998
We study the nonlinear firing and signal transduction of a neuron subject to both a constant stimulus and a weak periodic signal, each of which is too small to, separately, fire spikes for the neuron.
Wang, W, Wang, Y, Wang, ZD
core   +1 more source

Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning.

Circulation Research, 2015
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that by timely reperfusion is needed to reduce infarct size and improve ...
G. Heusch
semanticscholar   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Sentra: a database of signal transduction proteins for comparative genome analysis [PDF]

, 2006
Sentra (), a database of signal transduction proteins encoded in completely sequenced prokaryotic genomes, has been updated to reflect recent advances in understanding signal transduction events on a whole-genome scale.
D'Souza, Mark, Galperin, Michael Y., Glass, Elizabeth M., Maltsev, Natalia, Rodriguez, Alexis, Syed, Mustafa H., Zhang, Yi   +6 more
core   +4 more sources

PD1 signal transduction pathways in T cells

OncoTarget, 2017
The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low ...
H. Arasanz, M. Gato-Cañas, M. Zuazo, M. Ibáñez-Vea, K. Breckpot, G. Kochan, D. Escors   +6 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. [PDF]

, 2018
Cell-to-cell communication networks have critical roles in coordinating diverse organismal processes, such as tissue development or immune cell response. However, compared with intracellular signal transduction networks, the function and engineering
Altschuler, Steven J, Thurley, Kevin, Wu, Lani F   +2 more
core   +2 more sources