Results 71 to 80 of about 1,119,972 (297)

An Extended Filament Based Lamellipodium Model Produces Various Moving Cell Shapes in the Presence of Chemotactic Signals

, 2015
The Filament Based Lamellipodium Model (FBLM) is a two-phase two-dimensional continuum model, describing the dynamcis of two interacting families of locally parallel actin filaments (C.Schmeiser and D.Oelz, How do cells move?
Manhart, Angelika, Oelz, Dietmar, Schmeiser, Christian, Sfakianakis, Nikolaos   +3 more
core   +2 more sources

Role of cyclic AMP in the control of cell-specific gene expression [PDF]

, 1993
Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael, Nitsch, Doris, Schmid, Wolfgang, Schütz, Günther   +3 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Approximations and their consequences for dynamic modelling of signal transduction pathways [PDF]

, 2007
Signal transduction is the process by which the cell converts one kind of signal or stimulus into another. This involves a sequence of biochemical reactions, carried out by proteins.
Asthagiri, Atkins, Blüthgen, Briggs, Brightmann, Chen, Cho, Cornish-Bowden, Crampin, De Jong, Downward, Eissing, Eric Bullinger, Fell, Ferrell, Ferrell, Ferrell, Fowler, Goldbeter, Goldbeter, Hatakeyama, Heinrich, Heinrich, Huang, Johann Rohwer, Kholodenko, Kholodenko, Laurent, Lewis, Llórens, Markevich, Mathews, Michaelis, Novak, Olaf Wolkenhauer, Rubinow, Schilling, Schnell, Schoeberl, Segel, Swameye, Thomas Millat, Timmer, Tyson, Tzafriri, Winfree, Wolkenhauer, Wolkenhauer, Wolkenhauer, Yeung   +49 more
core   +1 more source

Signal transduction therapy.

Folia Pharmacologica Japonica, 1995
Signal transduction is essential for life. In living cells, several signal transduction pathways interact with each other to form complicated signal network. Second messengers, such as Ca2+, cAMP and cGMP, play fundamental roles in the cellular responses via binding to their target proteins. Recent advances in signal transduction research enables us to
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Signal-transduction [PDF]

Nature, 1987
G S, Whitley, J F, Tait
openaire   +3 more sources

DRASTIC—INSIGHTS:querying information in a plant gene expression database [PDF]

, 2005
DRASTIC––Database Resource for the Analysis of Signal Transduction In Cells (http://www.drastic.org.uk/) has been created as a first step towards a data-based approach for constructing signal transduction pathways.
Ball, Leslie D., Button, Davina K., Gartland, Jill S., Gartland, Kevan M. A., Lyon, Gary D., Natanson, Louis   +5 more
core   +3 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source