Results 281 to 290 of about 5,041,480 (330)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

TGF-β Signaling in the Pathophysiology of the Ovary: A Double-Edged Regulator. [PDF]

Biomolecules
Bertani N, Alteri A, Cacciottola L, D'Addato G, La Sala G, Lozanoska-Ochser B, Massimiani M, Parrella E, Reggio A, Russo E, Campolo F, Klinger FG.   +11 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Rewiring gene circuits to dissect oscillatory signaling dynamics. [PDF]

Genes Dev
van Oostrom MJ, Sonnen KF.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Spatiotemporal dynamics of mammalian wound healing. [PDF]

Cell Discov
Agramunt J, Kang Y, Rinkevich Y.
europepmc   +1 more source

Protective Effect and Mechanism of Rosiglitazone in α-amanitin-induced Hepatotoxicity Via Activation of PPAR-γ/Nrf2 Signaling Pathway. [PDF]

J Biochem Mol Toxicol
Lai F, Liao Y, Wu J, Wang T, Zhang G, Zhang X, Xia C, Hu J, Lu Y.   +8 more
europepmc   +1 more source

When Safety Fails to Update: Altered Dopamine Prediction Signals in Extinction-Deficient Mice. [PDF]

eNeuro
Hanafy MK.
europepmc   +1 more source