Results 291 to 300 of about 9,547,943 (379)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

The complex interplay between diabetes mellitus and pancreatic carcinogenesis: deciphering multifactorial mechanisms and identifying emerging therapeutic vulnerabilities. [PDF]

Cell Biosci
Lu CN, Liu JB, Chen ZY, Guo BT, Dong CS, Yu H, Tang XM, Liu J, Ji CX, Tao K, Kuang XD, Wu WG, Fu D.   +12 more
europepmc   +1 more source

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

No. V. Office of the Chief Signal Officer,UNITED STATE ARMY

, 1882

openalex   +2 more sources

Notch signaling in cancer: metabolic reprogramming and therapeutic implications. [PDF]

Front Immunol
Wang SS, Lv HL, Nie RZ, Liu YP, Hou YJ, Chen C, Tao XY, Luo HM, Li PF.   +8 more
europepmc   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

‘Biological Signals’ to ‘Biological Signals and Receptors’

Neurosignals, 1998
Pang, SF, Ward, PA, Cardinali, DP
openaire   +5 more sources

MosGraphFlow: a novel integrative graph AI model mining signaling targets from multi-omic data. [PDF]

BMC Methods
Zhang H, Cao D, Xu T, Chen E, Li G, Chen Y, Payne P, Province M, Li F.   +8 more
europepmc   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Cell-cell communication dysregulation in tuberous sclerosis complex cortical tubers and focal cortical dysplasia. [PDF]

Acta Neuropathol Commun
Scheper M, Anink JJ, Jansen FE, Van Hecke W, Mühlebner A, Mills JD, Aronica E.   +6 more
europepmc   +1 more source