Results 141 to 150 of about 403,629 (240)

Thein vitrofunctional profiles of fentanyl and nitazene analogs at the µ-opioid receptor - high efficacy is dangerous regardless of signaling bias

, 2023
Tsai MM, Chen L, Baumann MH, Canals M, Javitch JA, Lane JR, Shi L.   +6 more
europepmc   +1 more source

Structural insights into ligand-recognition, activation, and signaling-bias at the complement C5a receptor, C5aR1

, 2023
Saha S, Maharana J, Yadav MK, Sarma P, Singh V, Mohapatra S, Soni C, Saha S, Mishra S, Ganguly M, Chami M, Banerjee R, Shukla AK.   +12 more
europepmc   +1 more source

Molecular Glues: A New Approach to Modulating GPCR Signaling Bias. [PDF]

Biochemistry
Kushnir J, Gumpper RH.
europepmc   +1 more source

Challenging activity and signaling bias in tachykinin NK1 and NK2 receptors by truncated neuropeptides. [PDF]

J Biol Chem
Petersen JE, Pavlovskyi A, Madsen JJ, Schwartz TW, Frimurer TM, Olsen OH.   +5 more
europepmc   +1 more source

Mu Opioid Receptor Positive Allosteric Modulator BMS-986122 Confers Agonist-Dependent G Protein Subtype Signaling Bias. [PDF]

Biochemistry
Grieble GM, Knapp BI, Bidlack JM.
europepmc   +1 more source

Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors. [PDF]

J Biol Chem, 2019
Terrón-Díaz ME, Wright SJ, Agosto MA, Lichtarge O, Wensel TG.   +4 more
europepmc   +1 more source

Ezrin, Radixin, and Moesin Phosphorylation in NIH3T3 Cells Revealed Angiotensin II Type 1 Receptor Cell-Type–Dependent Biased Signaling

, 2013
Islam A.A.E.-H. Ibrahim, Michio Nakaya, Hitoshi Kurose   +2 more
openalex   +2 more sources

Beta-Arrestin Biased Signaling at a Class a GPCR: Modeling the ORG27569 Induced CB1/Beta-Arrestin 1 Complex [PDF]

, 2015
Dow P. Hurst, Diane L. Lynch, Derek M. Shore, Michael C. Pitman, Patricia H. Reggio   +4 more
openalex   +1 more source

Ovarian Cancer G protein-coupled receptor-1 signaling bias dictates anti-contractile effect of benzodiazepines on airway smooth muscle. [PDF]

Respir Res
Villalba DR, Jannu AK, Javed E, Dandekar I, Wang R, Deshpande DA, An SS, Panettieri RA, Tang DD, Penn RB, Nayak AP.   +10 more
europepmc   +1 more source

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity. [PDF]

Cell, 2019
Lotta LA, Mokrosiński J, Mendes de Oliveira E, Li C, Sharp SJ, Luan J, Brouwers B, Ayinampudi V, Bowker N, Kerrison N, Kaimakis V, Hoult D, Stewart ID, Wheeler E, Day FR, Perry JRB, Langenberg C, Wareham NJ, Farooqi IS.   +18 more
europepmc   +1 more source