Results 201 to 210 of about 403,629 (240)
Some of the next articles are maybe not open access.

Phase retrieval with signal bias

Journal of the Optical Society of America A, 2009
The effect of a uniform measurement bias, due to background light, stray light, detector dark current, or detector offset, on phase retrieval wavefront sensing algorithms is analyzed. Simulation results indicate that the root-mean-square error of the retrieved phase can be more sensitive to an unaccounted-for signal bias than to random noise in ...
Samuel T, Thurman, James R, Fienup
openaire   +2 more sources

Receiver bias for colourful signals

Animal Behaviour, 2003
Animals tend to respond more strongly to signals that are more colourful and such signals are also common in nature.
Liselotte Jansson, Magnus Enquist
openaire   +1 more source

Determining signaling bias

Science, 2018
GPCR Signaling G protein–coupled receptors (GPCRs) can mediate signaling through the G protein or β-arrestin pathways. Drugs that selectively activate one of these pathways provide effective treatment without side effects. GPCRs must undergo phosphorylation mediated by the GPCR kinase (GRK) family of kinases to recruit β-arrestins.
openaire   +1 more source

Flavors of GPCR signaling bias

Neuropharmacology
GPCRs are inherently flexible molecules existing in an equilibrium of multiple conformations. Binding of GPCR agonists shifts this equilibrium. Certain agonists can increase the fraction of active-like conformations that predispose the receptor to coupling to a particular signal transducer or a select group of transducers.
Mohammad Seyedabadi   +1 more
openaire   +2 more sources

Measurement of Receptor Signaling Bias

Current Protocols in Pharmacology, 2016
AbstractG protein–coupled receptors (GPCRs) are often pleiotropically linked to numerous cellular signaling mechanisms in cells, and it is now known that many agonists differentially activate some signaling pathways at the expense of others. The mechanism for this effect is the stabilization of different active receptor states by different agonists ...
openaire   +2 more sources

Signaling bias in drug discovery

Expert Opinion on Drug Discovery, 2017
The availability of different functional pharmacological assays has revealed that agonists for receptors that are pleiotropically coupled to multiple signaling pathways in the cell can emphasize signals to some pathways over others, i.e. can be biased toward certain signals.
openaire   +2 more sources

Estimation bias variation on beamformed signals

IEEE Transactions on Antennas and Propagation, 1995
Digital beamforming is widely used for estimating the direction of arrival (DOA) of signals incident on an array of antennas. It is well known that conventional beamforming has limited spatial resolution determined by the aperture of the array. It is also known that multiple signals incident on the array "bias" the DOA estimates of every other incident
M.A. Zatman   +3 more
openaire   +1 more source

The Measurement of Receptor Signaling Bias

2015
This chapter describes a method to quantify biased signaling effects of agonists; this approach can furnish a scale for medicinal chemists to optimize biased profiles. Biased ligands have different pharmacological properties on a molecular level (stabilization of different receptor active states) and thus can have different pharmacological profiles ...
openaire   +2 more sources

Home - About - Disclaimer - Privacy