Results 151 to 160 of about 1,476,364 (294)

SnapShot: Notch Signaling Pathway

Cell, 2007
Ilagan, Ma. Xenia G., Kopan, Raphael
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Signaling pathways and advances in targeted therapy for adenomyosis. [PDF]

Front Cell Dev Biol
Li Y, Zhang H, Ding Y, Zhao Y, Li Y, Qin T.   +5 more
europepmc   +1 more source

Coronary Serum Exosomes Derived from Patients with Myocardial Ischemia Regulate Angiogenesis through the miR-939-mediated Nitric Oxide Signaling Pathway [PDF]

, 2018
Hao Li, Yiteng Liao, Lei Gao, Tao Zhuang, Zheyong Huang, Hongming Zhu, Junbo Ge   +6 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Signaling Pathways Involved in Acute Pancreatitis

Journal of Inflammation Research
Mengchen Luo,1,* Ting Jin,1,* Yi Fang,1,* Feng Chen,1 Lujian Zhu,2 Jin Bai,3 Jin Ding1 1Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 2Department of ...
Luo M, Jin T, Fang Y, Chen F, Zhu L, Bai J, Ding J   +6 more
doaj  

Decoding TREM2 Signaling Pathways: Linking Macrophage Glycolysis to Inflammatory Diseases in the CNS. [PDF]

Neurol Neuroimmunol Neuroinflamm
Che Y, Yu Z, Ji S, Yang D.
europepmc   +1 more source

Wogonin induces apoptosis and endoplasmic reticulum stress in HL-60 leukemia cells through inhibition of the PI3K-AKT signaling pathway

, 2015
Chengjun Hu, Maozhong Xu, Rujuan Qin, Weifeng Chen, Xin Xu   +4 more
openalex   +2 more sources

Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production [PDF]

, 2019
Ruifang Wang, Yinxing Zhu, Xian Lin, Chenwei Ren, Jiachang Zhao, Fangfang Wang, Xiaochen Gao, Rong Xiao, Lianzhong Zhao, Huanchun Chen, Meilin Jin, Wenjun Ma, Hongbo Zhou   +12 more
openalex   +1 more source