Results 271 to 280 of about 1,476,364 (294)

Gibberellin signalling pathway

Current Opinion in Plant Biology, 2003
Recent molecular biological and genetical studies have identified several positive and negative regulators of gibberellin (GA) signalling pathways in higher plants. The DELLA protein functions as a negative regulator of GA signalling; its degradation through the ubiquitin/proteasome pathway is a key event in the regulation of GA-stimulated processes.
Kenji, Gomi, Makoto, Matsuoka
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Osteoclast signalling pathways

Biochemical and Biophysical Research Communications, 2005
The osteoclast is a monocyte-derived cell with complex regulatory control due to its role, balancing calcium homeostasis with skeletal modelling and repair. Normal differentiation requires tyrosine kinase- and tumor necrosis-family receptors, normally fms and RANK.
Harry C, Blair, Lisa J, Robinson, Mone, Zaidi   +2 more
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Notch Signaling Pathway

Science's STKE, 2006
Notch is a receptor that mediates intercellular signaling through a pathway conserved across the metazoa. It is involved in cell fate assignation and pattern formation during development. The receptor acts as a membrane-tethered transcription factor and is activated by members of the Delta, Serrate, Lag-2 family of Notch ligands, which trigger two ...
Matthias, Ehebauer, Penelope, Hayward, Alfonso, Martinez-Arias   +2 more
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Angiogenic Signalling Pathways

2008
Hypoxia is widely recognised as a key driving force for tumor angiogenesis by its induction of vascular endothelial growth factor (VEGF) and other direct-acting angiogenic factors. We describe the effect of hypoxia on gene expression and downstream angiogenic signalling; however, the angiogenic process is complex, and many other signalling pathways ...
Zubair, Ahmed, Roy, Bicknell
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Signal Transduction: Just another signalling pathway

Current Biology, 1994
The recently identified JAK-STAT signal transduction pathway plays a major role in signalling the arrival of cytokines at the cell surface and can, in part, account for the pleiotropic and redundant effects of cytokines.
J, Briscoe, D, Guschin, M, Müller
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Non-Smad signaling pathways

Cell and Tissue Research, 2011
Transforming growth factor-beta (TGFβ) is a key regulator of cell fate during embryogenesis and has also emerged as a potent driver of the epithelial-mesenchymal transition during tumor progression. TGFβ signals are transduced by transmembrane type I and type II serine/threonine kinase receptors (TβRI and TβRII, respectively). The activated TβR complex
Yabing, Mu, Shyam Kumar, Gudey, Maréne, Landström   +2 more
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The Ethylene Signaling Pathway

Science, 2004
Plants use a structurally very simple gas molecule, the hydrocarbon ethylene, to modulate various developmental programs and coordinate responses to a multitude of external stress factors. How this simple molecule generates such a diverse array of effects has been the subject of intense research for the past two decades.
Jose M, Alonso, Anna N, Stepanova
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Insulin signal transduction pathways

Trends in Endocrinology & Metabolism, 1994
Insulin initiates its pleiotropic effects by activating the insulin receptor tyrosine kinase to phosphorylate several intracellular proteins. Recent studies have demonstrated that phosphotyrosine residues bind specifically to proteins that contain src homology 2 (SH2) domains, and that this interaction mediates the regulation of multiple intracellular ...
M J, Quon, A J, Butte, S I, Taylor
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Cytokine receptor signaling pathways

Journal of Allergy and Clinical Immunology, 2000
Cytokines represent a diverse group of molecules that transmit intercellular signals. These signals may either be autocrine (where the same cell both produces the cytokine and responds to it) or paracrine (where the cytokine is made by one cell and acts on another). Both these situations can occur simultaneously.
W J, Leonard, J X, Lin
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Polyphenols: Novel Signaling Pathways

Current Pharmaceutical Design, 2018
Background: Cardiovascular disease (CVD) is currently the leading cause of death globally. The metabolic syndrome (MetS), a clustering of risk factors including hypertension, hyperglycemia, elevated low-density lipoprotein (LDL) cholesterol, reduced high-density lipoprotein (HDL) cholesterol and increased visceral adiposity, is a significant risk ...
Marie-Louise, Ricketts, Bradley S, Ferguson   +1 more
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