Results 31 to 40 of about 1,205 (263)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phyllopod at the intersection of developmental signalling pathways [PDF]

The EMBO Journal, 2009
One of the striking findings in developmental genetics over the past two decades is the realization that a very small number of conserved signalling pathways directs most, if not all, aspects of development of multicellular organisms, by transmitting extracellular signals to the cell nucleus, to modify gene expression programs.
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Conversion of Large Unsignalized Roundabout in Baghdad City to Signalized Intersection

Civil and Environmental Engineering
Rapid population growth in Iraq has influenced all aspects of life, including transportation networks. The substantial population growth immediately coincides with an increase in the number of vehicles using the traffic networks.
Kukaz Zahraa Salam, Jehad Ali Emad, Al-Rubaee Rasha Hassan, Mohammed Ammar Abbas   +3 more
doaj   +1 more source

Synchro Software-Based Alternatives for Improving Traffic Operations at Signalized Intersections

ARO-The Scientific Journal of Koya University, 2022
Traffic congestion is a considerable problem in urban arterials, especially at signalized intersections. Signalized intersections are critical elements of the highway system, thus improving their performance would significantly influence the overall ...
Nasreen A. Hussein
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Large Scale Evaluation of Normalized Hard-Braking Events Derived from Connected Vehicle Trajectory Data at Signalized Intersections, Roundabouts, and All-Way Stops

Future Transportation
Intersection safety has been traditionally evaluated using three to five years of crash data. Recent literature suggests that connected vehicle (CV)-derived hard braking (HB) events can provide a surrogate for crashes with only a few weeks or months of ...
Vihaan Vajpayee, Enrique D. Saldivar-Carranza, Rahul Suryakant Sakhare, Darcy M. Bullock   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Development of a Hybrid Artificial Neural Network-Particle Swarm Optimization Model for the Modelling of Traffic Flow of Vehicles at Signalized Road Intersections

Applied Sciences, 2021
The tremendous increase in vehicular navigation often witnessed daily has elicited constant and continuous traffic congestion at signalized road intersections.
Isaac Oyeyemi Olayode, Lagouge Kwanda Tartibu, Modestus O. Okwu, Uchechi Faithful Ukaegbu   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source