Results 41 to 50 of about 13,899 (284)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Development of a Hybrid Artificial Neural Network-Particle Swarm Optimization Model for the Modelling of Traffic Flow of Vehicles at Signalized Road Intersections

Applied Sciences, 2021
The tremendous increase in vehicular navigation often witnessed daily has elicited constant and continuous traffic congestion at signalized road intersections.
Isaac Oyeyemi Olayode, Lagouge Kwanda Tartibu, Modestus O. Okwu, Uchechi Faithful Ukaegbu   +3 more
doaj   +1 more source

KNOWLEDGE BASED TRAFFIC SIGNAL CONTROL MODEL FOR SIGNALIZED INTERSECTION

TRANSPORT, 2012
Intelligent transportation systems have received increasing attention in academy and industry. Being able to handle uncertainties and complexity, expert systems are applied in vast areas of real life including intelligent transportation systems. This paper presents a traffic signal control method based on expert knowledge for an isolated signalized ...
Pranevičius, Henrikas, Kraujalis, Tadas
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Conversion of Large Unsignalized Roundabout in Baghdad City to Signalized Intersection

Civil and Environmental Engineering
Rapid population growth in Iraq has influenced all aspects of life, including transportation networks. The substantial population growth immediately coincides with an increase in the number of vehicles using the traffic networks.
Kukaz Zahraa Salam, Jehad Ali Emad, Al-Rubaee Rasha Hassan, Mohammed Ammar Abbas   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Large Scale Evaluation of Normalized Hard-Braking Events Derived from Connected Vehicle Trajectory Data at Signalized Intersections, Roundabouts, and All-Way Stops

Future Transportation
Intersection safety has been traditionally evaluated using three to five years of crash data. Recent literature suggests that connected vehicle (CV)-derived hard braking (HB) events can provide a surrogate for crashes with only a few weeks or months of ...
Vihaan Vajpayee, Enrique D. Saldivar-Carranza, Rahul Suryakant Sakhare, Darcy M. Bullock   +3 more
doaj   +1 more source

CROSSING SPEEDS OF CARS THROUGH SIGNALIZED INTERSECTIONS

JOURNAL OF ENGINEERING SCIENCE, 2023
The article deals with the problem of traffic in three traffic-light intersections in the street network of Iasi city. Usually, the existing traffic lights do not fully take into account the size, structure and parameters of the queue of vehicles waiting at intersections; which in turn affects the traffic capacity of the intersection.
Narciza-Izabela Galusca, Silviu-Cristian Iriciuc, Gelu-Răzvan Gimiga, Diana-Nicoleta Dima, Maria-Cristina Scutaru   +4 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Accident Rates at Signalized Intersections

Transportation Research Procedia, 2017
Abstract Signalized intersections remain among the most common elements of street and road networks and types of traffic control. This is due to the fact that traffic safety at controlled intersections largely determines road safety in cities in general.
Shesterov, Eugene, Mikhailov, Alexander
openaire   +1 more source