Results 51 to 60 of about 298,592 (251)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Adaptive Control of Isolated Signalized Intersection using Neural Networks [PDF]

, 2019
Zbog sve većeg rasta prometne potražnje u gradskim sredinama dolazi do značajnog smanjenja razine uslužnosti mobilnosti u gradskim sredinama. Dio problema su i zastarjeli sustavi upravljanja semaforiziranim raskrižjem zasnovani na ustaljenim signalnim ...
Miletić, Mladen
core   +1 more source

Signalized Intersection Safety: A Case Study of Kollam Corporation

, 2022
In developing nations like India, motorization is increasing along with economic growth. Road traffic deaths in urban India have consistently been a serious issue of concern.
Lekshmi Sreekumar, Sai Nivedhitha M.G
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evaluating and Improving the Efficiency of Intersection of Freeway Off-Ramps with Arterial Roadway [PDF]

Engineering and Technology Journal, 2013
The signalized intersections are considering one of the critical elements in facility work of urban arterial roads. Thus, it is necessary to improve the signalized intersections system not only to increase the ability of flow on the major and minor roads
Atheer N. Hameed
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Effect of Countdown Timer with Running Text at Signalized Intersection: An Empirical Study

This study aims to analyze driving behaviour at signalized intersections due to the countdown timer. In the scenario, we also test the countdown timer with running text that lacks attention in the literature.
Rizka Dimas Fitrian, Agus Darmawan
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Traffic impacts analysis of bus stops near signalized intersections based on an optimal velocity model

Advances in Mechanical Engineering, 2019
The aim of this study is to investigate the impact of the bus stop near the signalized intersection on the traffic flow from two aspects, traffic volume and delay.
Zhenyu Liu, Meiying Jian
doaj   +1 more source